Literature DB >> 6770464

Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.

J H Dees, L D Coe, Y Yasukochi, B S Masters.   

Abstract

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.

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Year:  1980        PMID: 6770464     DOI: 10.1126/science.6770464

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  7 in total

1.  Regulation of arachidonic acid metabolism by cytochrome P-450 in rabbit kidney.

Authors:  M L Schwartzman; N G Abraham; M A Carroll; R D Levere; J C McGiff
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

2.  Variations in immunoreactivity for phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450, and NADPH-cytochrome P-450 reductase in rat liver over twenty-four hours.

Authors:  S Waguri; T Iyanagi; Y Uchiyama
Journal:  Histochemistry       Date:  1992

3.  Effects of cysteine and diethylmaleate pretreatments on renal function and response to a nephrotoxicant.

Authors:  M E Davis; W O Berndt; H M Mehendale
Journal:  Arch Toxicol       Date:  1986-05       Impact factor: 5.153

4.  Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.

Authors:  Cheng Fang; Melissa Behr; Fang Xie; Shijun Lu; Meghan Doret; Hongxiu Luo; Weizhu Yang; Kenneth Aldous; Xinxin Ding; Jun Gu
Journal:  Toxicol Appl Pharmacol       Date:  2007-10-23       Impact factor: 4.219

5.  The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.

Authors:  D C Zeldin; J D Plitman; J Kobayashi; R F Miller; J R Snapper; J R Falck; J L Szarek; R M Philpot; J H Capdevila
Journal:  J Clin Invest       Date:  1995-05       Impact factor: 14.808

6.  Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase.

Authors:  J Ozols
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

Review 7.  Immunohistochemical techniques and their applications in the histopathology of the respiratory system.

Authors:  I Linnoila; P Petrusz
Journal:  Environ Health Perspect       Date:  1984-06       Impact factor: 9.031

  7 in total

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