Once-daily sodium valproate in the treatment of epilepsy.

Using monotherapy with enteric-coated sodium valproate, seizures have been completely controlled in 35 patients with administration of the drug once daily, usually at night. The mean serum levels in seven patients were the same whether the drug was taken once or twice daily. The mean serum level was 65.4 mg/l on a mean daily dose of 19.4 mg/kg. Drowsiness in the morning occurred in four patients, but only one had to return to twice-daily administration. Compliance improves with once-daily administration.