Literature DB >> 6768875

Application of high-pressure liquid chromatography and thermal energy analyzer to analysis of trinitroglycerin and its metabolites in blood.

R J Spanggord, R G Keck.   

Abstract

A highly selective and sensitive analytical procedure for the determination of trinitroglycerin and four metabolites in whole blood was developed. Trinitroglycerin and its metabolites were extracted from whole blood with ethyl acetate and analyzed by high-pressure liquid chromatography using the thermal energy analyzer detector. Linearity of response was observed over the 1-1000-ng range. The applicability of this method to the analysis of whole blood from dogs orally dosed with trinitroglycerin is described.

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Year:  1980        PMID： 6768875     DOI： 10.1002/jps.2600690421

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  5 in total

1.  Glyceryl-1-nitrate pharmacokinetics in healthy volunteers.

Authors:  H Laufen; M Leitold
Journal:  Br J Clin Pharmacol       Date:  1987-03       Impact factor: 4.335

Review 2.  Clinical pharmacokinetics of glyceryl trinitrate following the use of systemic and topical preparations.

Authors:  M G Bogaert
Journal:  Clin Pharmacokinet       Date:  1987-01       Impact factor: 6.447

3.  Pharmacokinetics of oral glycerol-1-nitrate.

Authors:  H Laufen; M Leitold; R A Yeates
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

Review 4.  Clinical pharmacokinetics of organic nitrates.

Authors:  M G Bogaert
Journal:  Clin Pharmacokinet       Date:  1983 Sep-Oct       Impact factor: 6.447

5.  Capillary gas chromatographic (GC) analysis of nitroglycerin and its denitration products in plasma.

Authors:  A S Carlin; J E Simmons; G K Shiu; A O Sager; V K Prasad; J P Skelly
Journal:  Pharm Res       Date:  1988-02       Impact factor: 4.200
  5 in total

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