Literature DB >> 6768714

Absence of acetohydroxy acid synthetase in a clinical isolate of Neisseria gonorrhoeae requiring isoleucine and valine.

S A Lerner, E L Friedman, E J Dudek, G Kominski, M Bohnhoff, J A Morello.   

Abstract

A clinical isolate of Neisseria gonorrhoeae with an unusual growth requirement for isoleucine and valine lacked the activity of acetohydroxy acid synthetase, one of the enzymes required for the biosynthesis of these amino acids. A spontaneous mutant which no longer required isoleucine and valine had acquired this enzymatic activity.

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Year:  1980        PMID： 6768714      PMCID： PMC293968          DOI： 10.1128/jb.142.1.344-346.1980

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  THE BIOSYNTHESIS OF LEUCINE. II. THE ENZYMIC ISOMERIZATION OF BETA-CARBOXY-BETA-HYDROXYISOCAPROATE AND ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE.

Authors:  S R GROSS; R O BURNS; H E UMBARGER
Journal:  Biochemistry       Date:  1963 Sep-Oct       Impact factor: 3.162

2.  THE BIOSYNTHESIS OF LEUCINE. III. THE CONVERSION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE TO ALPHA-KETOISOCAPROATE.

Authors:  R O BURNS; H E UMBARGER; S R GROSS
Journal:  Biochemistry       Date:  1963 Sep-Oct       Impact factor: 3.162

3.  CONTROL OF ISOLEUCINE, VALINE AND LEUCINE BIOSYNTHESIS. II. ENDPRODUCT INHIBITION BY VALINE OF ACETOHYDROXY ACID SYNTHETASE IN SALMONELLA TYPHIMURIUM.

Authors:  R H BAUERLE; M FRUENDLICH; F C STORMER; H E UMBARGER
Journal:  Biochim Biophys Acta       Date:  1964-10-23

4.  Isoleucine and valine metabolism in Escherichia coli. X. The enzymatic formation of acetohydroxybutyrate.

Authors:  R I LEAVITT; H E UMBARGER
Journal:  J Biol Chem       Date:  1961-09       Impact factor: 5.157

5.  THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. I. ENZYMATIC TRANSFORMATION OF THE DIHYDROXY ACID PRECURSORS TO THE KETO ACID PRECURSORS.

Authors:  J W Myers; E A Adelberg
Journal:  Proc Natl Acad Sci U S A       Date:  1954-06       Impact factor: 11.205

6.  Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections.

Authors:  J A Morello; S A Lerner; M Bohnhoff
Journal:  Infect Immun       Date:  1976-05       Impact factor: 3.441

7.  Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements.

Authors:  J S Knapp; K K Holmes
Journal:  J Infect Dis       Date:  1975-08       Impact factor: 5.226

8.  Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine.

Authors:  A Szentirmai; M Szentirmai; H E Umbarger
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

9.  REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. 3. MAP ORDER OF THE STRUCTURAL GENES AND OPERATOR GENES.

Authors:  T RAMAKRISHNAN; E A ADELBERG
Journal:  J Bacteriol       Date:  1965-03       Impact factor: 3.490

10.  Development of a defined minimal medium for the growth of Neisseria gonorrhoeae.

Authors:  L J La Scolea; F E Young
Journal:  Appl Microbiol       Date:  1974-07
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