Literature DB >> 6768444

Tumour initiation in mouse skin by 7,12-dimethylbenz[a]anthracene: irrelevance of systemic activation.

W G Pyerin, E Hecker.   

Abstract

The effect was investigated of 7,8-benzoflavone (BF) on tumour initiation by 7,12-dimethylbenz[a]anthracene (DMBA) applied either intragastrically or topically. A single topical application of BF drastically decreased tumour initiation via both routes. This decrease was in both cases inversely proportional to the interval between administration of DMBA and BF. The data suggest that the decisive step of metabolic activation of DMBA is mediated by cytochrome P-448 dependent monooxygenase(s) located within the epidermis.

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Year:  1980        PMID： 6768444     DOI： 10.1016/0304-3835(80)90147-0

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  3 in total

1.  Posttranslational modifications of the cytochrome P-450 monooxygenase system.

Authors:  W Pyerin; F Horn; H Taniguchi
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

2.  Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine.

Authors:  W P Tang; P G Huang; M L Zhao; S L Liao; Y Zeng
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

3.  Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.

Authors:  K Goerttler; H Loehrke; J Schweizer; B Hesse
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553
  3 in total

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