| Literature DB >> 6768424 |
G A Monti Graziadei, M S Karlan, J J Bernstein, P P Graziadei.
Abstract
Section of the fila olfactoria in squirrel monkey, a non-human primate, induces rapid degeneration of the sensory axon terminals in the olfactory bulb glomeruli. A population of axons, from newly formed sensory neurons in the olfactory neuroepithelium, regrow, passes the lamina cribrosa and, upon reaching the olfactory bulb, reinnervates the glomeruli. A new set of synaptic contacts is reformed between the sensory terminals and the post-synaptic dendritic processes of the glomeruli. Our observations indicate that this portion of the CNS of a non-human primate can be reinnervated after deafferentiation, and that active synaptogenesis occurs.Entities:
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Year: 1980 PMID： 6768424 DOI： 10.1016/0006-8993(80)90095-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252