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Literature DB >> 6768088

The effects of naloxone on methylphenidate-induced mood and behavioral changes: a negative study.

L Y Huey, D S Janowsky, L L Judd, N A Roitman, P L Clopton, D Segal, L Hall, D Parker.

Abstract

The effects of naloxone on IV methylphenidate-induced mood, behavior, and neurohumoral changes were assessed in eight psychiatric inpatients. While methylphenidate alone produced anticipated changes, the indications for significant naloxone-methylphenidate interactions were minimal. It is speculated that larger doses of naloxone might be required to produce modification of the psychostimulant effects.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 6768088 DOI： 10.1007/bf00431966

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

26 in total

Review 1. In vivo receptor occupation by opiates and correlation to the pharmacological effect.

Authors: V Höllt; A Herz
Journal: Fed Proc Date: 1978-02

2. Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin--evidence for regulation by an endogenous opioid peptide in brain.

Authors: C J Shaar; R C Frederickson; N B Dininger; L Jackson
Journal: Life Sci Date: 1977-09-15 Impact factor: 5.037

The effects of naloxone on methylphenidate-induced mood and behavioral changes: a negative study.

Review 1. In vivo receptor occupation by opiates and correlation to the pharmacological effect.

2. Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin--evidence for regulation by an endogenous opioid peptide in brain.

3. Behavioral effects of separate and combined administration of naloxone and d-amphetamine.

4. Provocation of schizophrenic symptoms by intravenous administration of methylphenidate.

5. Sleep-related, nychthermeral and briefly episodic variation in human plasma prolactin concentrations.

6. Prolactin secretion, a measurable central effect of opiate-receptor antagonists.

7. The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis.

8. Naloxone in chronic schizophrenia.

9. Intravenous naloxone administration in schizophrenia and affective illness.

10. Increased CSF levels of endorphines in chronic psychosis.

1. Influence of naloxone upon motor activity induced by psychomotor stimulant drugs.