Literature DB >> 6768007

Protein binding of valproic acid in uremic patients.

J Bruni, L H Wang, T C Marbury, C S Lee, B J Wilder.   

Abstract

Protein binding of valproic acid was studied in four uremic patients on long-term hemodialysis. Before dialysis, the free fraction was 0.31 +/- 0.11 (SD); this was larger than in nonuremic subjects. During hemodialysis, the free fraction increased significantly (p less than 0.01) in three patients (mean, 0.64 +/- 0.32 SD).

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Year:  1980        PMID： 6768007     DOI： 10.1212/wnl.30.5.557-a

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

Review 1.  Disease-induced variations in plasma protein levels. Implications for drug dosage regimens (Part II).

Authors:  R Zini; P Riant; J Barré; J P Tillement
Journal:  Clin Pharmacokinet       Date:  1990-09       Impact factor: 6.447

Review 2.  Pharmacokinetic of antiepileptic drugs in patients with hepatic or renal impairment.

Authors:  Gail D Anderson; Shahin Hakimian
Journal:  Clin Pharmacokinet       Date:  2014-01       Impact factor: 6.447

3.  Alteration of drug-protein binding in renal disease.

Authors:  M M Reidenberg; D E Drayer
Journal:  Clin Pharmacokinet       Date:  1984-01       Impact factor: 6.447

4.  Free level monitoring of antiepileptic drugs. Clinical usefulness and case studies.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1984-01       Impact factor: 6.447

5.  Pitfalls of pharmacokinetic dosage guidelines in renal insufficiency.

Authors:  K Turnheim
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 6.  Free drug concentration monitoring in clinical practice. Rationale and current status.

Authors:  C K Svensson; M N Woodruff; J G Baxter; D Lalka
Journal:  Clin Pharmacokinet       Date:  1986 Nov-Dec       Impact factor: 6.447

Review 7.  Drug therapy in patients undergoing haemodialysis. Clinical pharmacokinetic considerations.

Authors:  C S Lee; T C Marbury
Journal:  Clin Pharmacokinet       Date:  1984 Jan-Feb       Impact factor: 6.447

8.  Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients.

Authors:  J J Marty; C J Kilpatrick; R F Moulds
Journal:  Br J Clin Pharmacol       Date:  1982-09       Impact factor: 4.335

9.  Distribution of sodium valproate in normal whole blood and in blood from patients with renal or hepatic disease.

Authors:  R J Shirkey; L B Jellett; D C Kappatos; T J Maling; A Macdonald
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

10.  Decreased plasma protein binding of valproate in patients with acute head trauma.

Authors:  G D Anderson; B E Gidal; R J Hendryx; A B Awan; N R Temkin; A J Wilensky; H R Winn
Journal:  Br J Clin Pharmacol       Date:  1994-06       Impact factor: 4.335
  10 in total

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