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Literature DB >> 6767887

N-Hydroxymethylpentamethylmelamine, a major in vitro metabolite of hexamethylmelamine.

A Gescher, M D'Incalci, R Fanelli, P Farina.

Abstract

Entities: Chemical

Mesh：

Substances：
Triazines
NADP
Altretamine

Year: 1980 PMID： 6767887 DOI： 10.1016/0024-3205(80)90059-4

Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037

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Cited

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10 in total

1. Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration.

Authors: J Dubois; G Atassi; M Hanocq; F Abikhalil
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

Review 2. Active drug metabolites. An overview of their relevance in clinical pharmacokinetics.

Authors: S Garattini
Journal: Clin Pharmacokinet Date: 1985 May-Jun Impact factor: 6.447

3. The comparative pharmacokinetics of pentamethylmelamine in man, rat, and mouse.

Authors: C J Rutty; D R Newell; J R Muindi; K R Harrap
Journal: Cancer Chemother Pharmacol Date: 1982 Impact factor: 3.333

Review 4. N-methyl antitumour agents. A distinct class of anticancer drugs?

Authors: D Newell; A Gescher; S Harland; D Ross; C Rutty
Journal: Cancer Chemother Pharmacol Date: 1987 Impact factor: 3.333

5. Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma.

Authors: E Garattini; T Colombo; M G Donelli; P Catalani; M Bianchi; M D'Incalci; C Pantarotto
Journal: Cancer Chemother Pharmacol Date: 1983 Impact factor: 3.333

6. Effect of a hepatic activation system on the antiproliferative activity of hexamethylmelamine against human tumor cell lines.

Authors: K J Miller; R M McGovern; M M Ames
Journal: Cancer Chemother Pharmacol Date: 1985 Impact factor: 3.333

N-Hydroxymethylpentamethylmelamine, a major in vitro metabolite of hexamethylmelamine.

1. Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration.

Review 2. Active drug metabolites. An overview of their relevance in clinical pharmacokinetics.

3. The comparative pharmacokinetics of pentamethylmelamine in man, rat, and mouse.

Review 4. N-methyl antitumour agents. A distinct class of anticancer drugs?

5. Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma.

6. Effect of a hepatic activation system on the antiproliferative activity of hexamethylmelamine against human tumor cell lines.

Review 7. Clinical pharmacokinetics of altretamine.

Review 8. Hexamethylmelamine and hexamethylmelamine hydrochloride.

9. Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites.

10. Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.