| Literature DB >> 6767791 |
R C Moellering, B E Murray, S C Schoenbaum, J Adler, C B Wennersten.
Abstract
A patient with enterococcal endocarditis, who relapsed after repeated courses of apparently adequate treatment with ampicillin plus gentamicin, was subsequently cured with ampicillin-tobramycin therapy. The organisms isolated from this patient were strains of Streptococcus faecalis that were resistant to penicillin (or ampicillin)-gentamicin synergism but not to penicillin (or ampicillin)-tobramycin synergism. The mechanism of resistance in these strains appears to be related to a specific defect in the intracellular uptake of gentamicin (but not tobramycin) in the presence of penicillin.Entities:
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Year: 1980 PMID： 6767791 DOI： 10.1093/infdis/141.1.81
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226