Literature DB >> 6767611

Pharmacokinetics of chlorthalidone. Dependence of biological half life on blood carbonic anhydrase levels.

B A Mulley, G D Parr, R M Rye.   

Abstract

The relationship between the whole blood concentration of carbonic anhydrase and the biological half life of chlorthalidone has been investigated in six volunteers. A linear relationship was observed and on the basis of this, a pharmacokinetic model to explain the long and variable biological half life of chlorthalidone is proposed and discussed.

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Year:  1980        PMID： 6767611     DOI： 10.1007/bf00561901

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  11 in total

1.  [Hygroton (G 33,182), a new saluretic and diuretic with protracted action].

Authors:  E G STENGER; H WIRZ; R PULVER
Journal:  Schweiz Med Wochenschr       Date:  1959-10-24

2.  [The diuretic effect of new sulfamyl derivatives].

Authors:  E G STENGER
Journal:  Bull Schweiz Akad Med Wiss       Date:  1959-09

3.  Nonlinear relationship between plasma and red blood cell pharmacokinetics of chlorthalidone in man.

Authors:  H L Fleuren; J M van Rossum
Journal:  J Pharmacokinet Biopharm       Date:  1977-08

4.  Rapid evaluation of creatinine clearance.

Authors:  K Siersbaek-Nielsen; J M Hansen; J Kampmann; M Kristensen
Journal:  Lancet       Date:  1971-05-29       Impact factor: 79.321

5.  Application of the extractive alkylation technique to the gas chromatographic determination of chlorthalidone in plasma in nanogram quantities.

Authors:  M Ervik; K Gustavii
Journal:  Anal Chem       Date:  1974-01       Impact factor: 6.986

6.  Improved method for estimating chlorthalidone in body fluids.

Authors:  M G Tweeddale; R I Ogilvie
Journal:  J Pharm Sci       Date:  1974-07       Impact factor: 3.534

7.  Placental transfer of chlorthalidone and its elimination in maternal milk.

Authors:  B A Mulley; G D Parr; W K Pau; R M Rye; J J Mould; N C Siddle
Journal:  Eur J Clin Pharmacol       Date:  1978-05-17       Impact factor: 2.953

8.  Pharmacokinetic studies with chlorthalidone (Hygroton) in man.

Authors:  W Riess; U C Dubach; D Burckhardt; W Theobald; P Vuillard; M Zimmerli
Journal:  Eur J Clin Pharmacol       Date:  1977-12-16       Impact factor: 2.953

9.  Binding-site interaction of chlorthalidone and acetazolamide, two drugs transported by red blood cells.

Authors:  B Beermann; K Hellström; B Lindström; A Rosén
Journal:  Clin Pharmacol Ther       Date:  1975-04       Impact factor: 6.875

10.  Absolute bioavailability of chlorthalidone in man: a cross-over study after intravenous and oral administration.

Authors:  H L Fleuren; T A Thien; C P Verwey-van Wissen; J M van Rossum
Journal:  Eur J Clin Pharmacol       Date:  1979-02-19       Impact factor: 2.953
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  4 in total

Review 1.  Guide to drug dosage in renal failure.

Authors:  W M Bennett
Journal:  Clin Pharmacokinet       Date:  1988-11       Impact factor: 6.447

2.  Pharmacokinetics of chlorthalidone in the elderly after single and multiple doses.

Authors:  D Colussi; J P Schoeller; A Richard; A Sioufi
Journal:  Br J Clin Pharmacol       Date:  1983-12       Impact factor: 4.335

3.  Binding of sulfonamides to carbonic anhydrase: influence on distribution within blood and on pharmacokinetics.

Authors:  A Boddy; P Edwards; M Rowland
Journal:  Pharm Res       Date:  1989-03       Impact factor: 4.200

4.  Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4-5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial.

Authors:  Fabio Solis-Jimenez; Lucia Monserrat Perez-Navarro; Ricardo Cabrera-Barron; Jesus Antonio Chida-Romero; Geovana Martin-Alemañy; Edgar Dehesa-López; Magdalena Madero; Rafael Valdez-Ortiz
Journal:  BMC Nephrol       Date:  2022-09-20       Impact factor: 2.585
  4 in total

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