Literature DB >> 6767405

Mechanism of induction of luteal phase defects by danazol.

R H Asch, E O Fernandez, T M Siler-Khodr, A Bartke, C J Pauerstein.   

Abstract

The effects of danazol on the luteal phase of cycling rhesus monkeys and on the ability of the intact rhesus monkey to respond to hCG stimulation were studied in two experiments. In a third experiment the impact of danazol upon the response of the decapsulated mouse testis to hCG stimulation was evaluated. These experiments demonstrated that danazol shortens the luteal phase and decreases progesterone production in intact monkeys via a direct effect on the gonad.

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Year:  1980        PMID: 6767405     DOI: 10.1016/0002-9378(80)91054-6

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  3 in total

1.  Proceedings of the Fiftieth Anniversary Meeting of the British Pharmacological Society, University of Oxford, 16-18 September 1981. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1981-12       Impact factor: 8.739

2.  Corpus luteum dysfunction and the epidemiology of breast cancer: a reconsideration.

Authors:  B M Sherman; R B Wallace; S G Korenman
Journal:  Breast Cancer Res Treat       Date:  1981       Impact factor: 4.872

3.  Effects of danazol on steroidogenesis and gonadotropic responsiveness in isolated human preovulatory follicular cells.

Authors:  J H Olsson; B Dennefors; L Nilsson
Journal:  J Endocrinol Invest       Date:  1986-04       Impact factor: 4.256

  3 in total

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