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Literature DB >> 6767272

Cytochrome p-450: localization in rabbit lung.

C J Serabjit-Singh, C R Wolf, R M Philpot, C G Plopper.

Abstract

Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foriegn compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.

Entities: Chemical Disease Gene Species

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Year: 1980 PMID： 6767272 DOI： 10.1126/science.6767272

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

24 in total

1. Formation of genotoxic products from N-nitrosoheptamethyleneimine (NHMI), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) by isolated rabbit lung cells.

Authors: J E Dahl; R Becher; M Låg; H M Schuller; E Dybing
Journal: Cell Biol Toxicol Date: 1990-10 Impact factor: 6.691

2. The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

Authors: G I Murray; T S Barnes; H F Sewell; S W Ewen; W T Melvin; M D Burke
Journal: Br J Clin Pharmacol Date: 1988-04 Impact factor: 4.335

3. Species differences in short term toxicity from inhalation exposure to bromobenzene.

Authors: J E Dahl; R Becher; K Aarstad; O G Nilsen; E Dybing
Journal: Arch Toxicol Date: 1990 Impact factor: 5.153

4. Ultrastructural and immunohistochemical studies on non-ciliated cells of the tracheal epithelium of normal, phenobarbital-treated and 3-methylcholanthrene-treated mice.

Authors: K Ishimura; M Usa; H Fujita; S Kawata; M Okamoto; T Yamano
Journal: Cell Tissue Res Date: 1985 Impact factor: 5.249

Cytochrome p-450: localization in rabbit lung.

1. Formation of genotoxic products from N-nitrosoheptamethyleneimine (NHMI), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) by isolated rabbit lung cells.

2. The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

3. Species differences in short term toxicity from inhalation exposure to bromobenzene.

4. Ultrastructural and immunohistochemical studies on non-ciliated cells of the tracheal epithelium of normal, phenobarbital-treated and 3-methylcholanthrene-treated mice.

5. Mixed-function oxidase activity in enriched populations of ciliated cells freshly isolated from rabbit tracheas.

6. In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung.

7. Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells.

8. m-Xylene inhalation destroys cytochrome P-450 in rat lung at low exposure.

9. Glycogen accumulation in alveolar type II cells in 3-methylindole--induced pulmonary edema in goats.

10. Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice.