Literature DB >> 6767191

Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity.

T H Rabbitts, G Matthyssens, P H Hamlyn.   

Abstract

A mouse cloned cDNA probe containing a variable (V) region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in this subgroup of mouse and human DNA. There seem to be about 10 and 20 VH-genes hybridising to this probe in mouse and human DNA, respectively. Studies of cross-hybridisation of the related VK-genes from MOPC21 and MPC11 myelomas indicate that the experiments detect all members of the VHIII subgroup.

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Year:  1980        PMID： 6767191     DOI： 10.1038/284238a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  18 in total

1.  Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.

Authors:  S Munir Alam; Hua-Xin Liao; S Moses Dennison; Frederick Jaeger; Robert Parks; Kara Anasti; Andrew Foulger; Michele Donathan; Judith Lucas; Laurent Verkoczy; Nathan Nicely; Georgia D Tomaras; Garnett Kelsoe; Bing Chen; Thomas B Kepler; Barton F Haynes
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

2.  Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements.

Authors:  G W Litman; K Murphy; L Berger; R Litman; K Hinds; B W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

3.  Multiple components in restriction enzyme digests of mammalian (insectivore), avian and reptilian genomic DNA hybridize with murine immunoglobulin VH probes.

Authors:  G W Litman; L Berger; C L Jahn
Journal:  Nucleic Acids Res       Date:  1982-06-11       Impact factor: 16.971

4.  Simple DNA sequences in homologous flanking regions near immunoglobulin VH genes: a role in gene interaction?

Authors:  J B Cohen; K Effron; G Rechavi; Y Ben-Neriah; R Zakut; D Givol
Journal:  Nucleic Acids Res       Date:  1982-06-11       Impact factor: 16.971

5.  Structural relationships among mouse and human immunoglobulin VH genes in the subgroup III.

Authors:  R Ollo; J L Sikorav; F Rougeon
Journal:  Nucleic Acids Res       Date:  1983-11-25       Impact factor: 16.971

6.  Transcriptional regulation of immunoglobulin V genes.

Authors:  E L Mather; R P Perry
Journal:  Nucleic Acids Res       Date:  1981-12-21       Impact factor: 16.971

7.  Single amino acid substitution altering antigen-binding specificity.

Authors:  S Rudikoff; A M Giusti; W D Cook; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

8.  Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.

Authors:  D J Kemp; A W Harris; J M Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

Authors:  G Matthyssens; T H Rabbitts
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

10.  Mouse heavy chain variable regions: nucleotide sequence of a germ-line VH gene segment.

Authors:  R Ollo; C Auffray; J L Sikorav; F Rougeon
Journal:  Nucleic Acids Res       Date:  1981-08-25       Impact factor: 16.971
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