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Literature DB >> 6766902

Dengue-2 vaccine: preparation from a small-plaque virus clone.

K H Eckels, V R Harrison, P L Summers, P K Russell.

Abstract

The S-1 clone of dengue type 2 virus was used for the preparation of a live-attenuated vaccine after passage in DBS-FRhL-2 cell culture. The vaccine virus had a relatively higher replicative capacity at superoptimal temperatures than its precursor virus, S-1, passaged in primary green monkey kidney cells (S-1 PGMK). There was also a tendency for the S-1 vaccine virus to exhibit leakiness at increased temperatures. Another in vitro marker, replication in monkey peripheral blood leukocytes, indicated less host restriction for the S-1 vaccine in comparative assays with S-1 PGMK virus. Mouse virulence appeared to remain stable on passage in DBS-FRhL-2 cells, whereas monkey immunogenicity decreased. Cautious trials of the dengue type 2 S-1 vaccine in humans are indicated.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6766902 PMCID： PMC550740 DOI： 10.1128/iai.27.1.175-180.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. STUDIES ON JAPANESE B ENCEPHALITIS VIRUS VACCINES FROM TISSUE CULTURE. IV. PREPARATION AND CHARACTERIZATION OF POOL OF ATTENUATED OCT-541 LINE FOR HUMAN VACCINE TRIAL.

Authors: W M HAMMON; S ROHITAYODHIN; J S RHIM
Journal: J Immunol Date: 1963-09 Impact factor: 5.422

2. Two variants of tick-borne encephalitis virus showing different plaque morphology.

Authors: V MAYER
Journal: Virology Date: 1963-06 Impact factor: 3.616

3. Clinical and serologic response of man to immunization with attenuated dengue and yellow fever viruses.

Authors: W R DORRANCE; J W FRANKEL; I GORDON; P R PATTERSON; R W SCHLESINGER; J W WINTER
Journal: J Immunol Date: 1956-11 Impact factor: 5.422

4. A spontaneous temperature sensitive mutant of Japanese encephalitis virus: preliminary characterization.

Authors: S Halle; E Zebovitz
Journal: Arch Virol Date: 1977 Impact factor: 2.574

5. Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production.

Authors: R E Wallace; P J Vasington; J C Petricciani; H E Hopps; D E Lorenz; Z Kadanka
Journal: In Vitro Date: 1973 Mar-Apr

6. Pandemic dengue in Caribbean countries and the southern United States--past, present and potential problems.

Authors: N J Ehrenkranz; A K Ventura; R R Cuadrado; W L Pond; J E Porter
Journal: N Engl J Med Date: 1971-12-23 Impact factor: 91.245

7. Demonstration of infectious DNA in transformed cells. II. Characterization of uptake of SV40-transformed mouse cell DNA by simian cells.

Authors: R K Kelly; J S Butel
Journal: Arch Virol Date: 1975 Impact factor: 2.574

8. Chemically induced temperature-sensitive mutants of dengue virus type 2: comparison of temperature sensitivity in vitro with infectivity suckling mice, hamsters, and rhesus monkeys.

Authors: G C Tarr; A S Lubiniecki
Journal: Infect Immun Date: 1976-03 Impact factor: 3.441

9. Dengue-2 vaccine: viremia and immune responses in rhesus monkeys.

Authors: R M Scott; A Nisalak; K H Eckels; M Tingpalapong; V R Harrison; D J Gould; F E Chapple; P K Russell
Journal: Infect Immun Date: 1980-01 Impact factor: 3.441

10. PRODUCTION OF IMMUNITY TO DENGUE WITH VIRUS MODIFIED BY PROPAGATION IN MICE.

Authors: A B Sabin; R W Schlesinger
Journal: Science Date: 1945-06-22 Impact factor: 47.728

19 in total

1. Expression of the structural proteins of dengue 2 virus and yellow fever virus by recombinant vaccinia viruses.

Authors: Y S Hahn; E M Lenches; R Galler; C M Rice; J Dalrymple; J H Strauss
Journal: Arch Virol Date: 1990 Impact factor: 2.574

2. A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice.

Authors: Alexander A Rumyantsev; Brian R Murphy; Alexander G Pletnev
Journal: J Virol Date: 2006-02 Impact factor: 5.103

3. Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.

Authors: Kathryn A Hanley; Jay J Lee; Joseph E Blaney; Brian R Murphy; Stephen S Whitehead
Journal: J Virol Date: 2002-01 Impact factor: 5.103

4. In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3.

Authors: F Preugschat; C W Yao; J H Strauss
Journal: J Virol Date: 1990-09 Impact factor: 5.103

5. Fetal rhesus monkey lung cells can be grown in serum-free medium for the replication of dengue-2 vaccine virus.

Authors: B Malewicz; L E Anderson; K Crilly; H M Jenkin
Journal: In Vitro Cell Dev Biol Date: 1985-08

6. Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice.

Authors: J E Blaney; D H Johnson; C Y Firestone; C T Hanson; B R Murphy; S S Whitehead
Journal: J Virol Date: 2001-10 Impact factor: 5.103

Review 7. The dengue viruses.

Authors: E A Henchal; J R Putnak
Journal: Clin Microbiol Rev Date: 1990-10 Impact factor: 26.132