Literature DB >> 6766863

The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes.

S Miyazawa, T Osumi, T Hashimoto.   

Abstract

A novel 3-oxacyl-CoA thiolase was found in rat liver. This thiolase, mitochondrial general 3-oxacyl-CoA thiolase and acetoacetyl-CoA thiolase were purified from the rat liver after the induction of these activities by the administration to rats of di(2-ethylhexyl)phthalate, which enhanced the peroxisomal beta-oxidation activity. The new 3-oxoacyl-CoA thiolase was distinguished from mitochondrial and cytoplasmic thiolases by the following: DEAE-cellulose chromatography, phosphocellulose chromatography, immunochemical titration, and substrate specificity. Subcellular fractionation of liver and sucrose-density-gradient centrifugation of the light mitochondrial fraction revealed that the new thiolase was mainly in peroxisomes.

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Year:  1980        PMID： 6766863     DOI： 10.1111/j.1432-1033.1980.tb05984.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  47 in total

Review 1.  Peroxisomal beta-oxidation enzymes.

Authors:  T Hashimoto
Journal:  Neurochem Res       Date:  1999-04       Impact factor: 3.996

Review 2.  Peroxisomal disorders: clinical, biochemical, and molecular aspects.

Authors:  R J Wanders
Journal:  Neurochem Res       Date:  1999-04       Impact factor: 3.996

3.  Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes.

Authors:  J C Igual; C González-Bosch; J Dopazo; J E Pérez-Ortín
Journal:  J Mol Evol       Date:  1992-08       Impact factor: 2.395

4.  Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of a new inborn error of mitochondrial fatty acid beta-oxidation.

Authors:  R J Wanders; L IJlst; A H van Gennip; C Jakobs; J P de Jager; L Dorland; F J van Sprang; M Duran
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

5.  D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder.

Authors:  Y Suzuki; L L Jiang; M Souri; S Miyazawa; S Fukuda; Z Zhang; M Une; N Shimozawa; N Kondo; T Orii; T Hashimoto
Journal:  Am J Hum Genet       Date:  1997-11       Impact factor: 11.025

6.  Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits.

Authors:  S Ushikubo; T Aoyama; T Kamijo; R J Wanders; P Rinaldo; J Vockley; T Hashimoto
Journal:  Am J Hum Genet       Date:  1996-05       Impact factor: 11.025

7.  Immunohistochemical localization of mitochondrial fatty acid β-oxidation enzymes in Müller cells of the retina.

Authors:  Kimie Atsuzawa; Ayami Nakazawa; Kenmei Mizutani; Motoaki Fukasawa; Naoki Yamamoto; Takashi Hashimoto; Nobuteru Usuda
Journal:  Histochem Cell Biol       Date:  2010-11-03       Impact factor: 4.304

8.  Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: implications for peroxisomal beta-oxidation disorders.

Authors:  R J Wanders; S Denis; E van Berkel; F Wouters; K W Wirtz; U Seedorf
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

9.  Innermembrane association of three mitochondrial beta-oxidation enzymes revealed by immunoelectron microscopic technique.

Authors:  S Yokota; T Hashimoto
Journal:  Histochemistry       Date:  1984

Review 10.  Mitochondrial 2-methylacetoacetyl-CoA thiolase deficiency: an inborn error of isoleucine and ketone body metabolism.

Authors:  O Søvik
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982
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