Literature DB >> 6766732

Keratitis due to Aspergillus flavus successfully treated with thiabendazole.

M P Upadhyay, E P West, A P Sharma.   

Abstract

A case of Aspergillus flavus keratitis treated successfully with 4% suspension of thiabendazole is reported. This seems to be the first case of successful treatment of keratomycosis with thiabendazole. All other reported cases treated with this drug either had their eyes removed or did not retain any useful vision. Its ability to penetrate ocular tissues, ability to remain in concentrations higher than the minimal inhibitory concentration of many fungi, and broad spectrum of activity make it a worthwhile drug for further investigation in keratomycosis.

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Year:  1980        PMID: 6766732      PMCID: PMC1039343          DOI: 10.1136/bjo.64.1.30

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  9 in total

1.  ANTIMYCOTIC PROPERTIES OF THIABENDAZOLE.

Authors:  H J ROBINSON; H F PHARES; O E GRAESSLE
Journal:  J Invest Dermatol       Date:  1964-06       Impact factor: 8.551

2.  STUDIES ON THE TOXICOLOGIC AND PHARMACOLOGIC PROPERTIES OF THIABENDAZOLE.

Authors:  H J ROBINSON; H C STOERK; O E GRAESSLE
Journal:  Toxicol Appl Pharmacol       Date:  1965-01       Impact factor: 4.219

3.  Clotrimazole in the treatment of ocular infection by Aspergillus fumigatus.

Authors:  B R Jones; A B Richards
Journal:  Postgrad Med J       Date:  1974-07       Impact factor: 2.401

Review 4.  Thiabendazole: toxicological, pharmacological and antifungal properties.

Authors:  H J Robinson; R H Silber; O E Graessle
Journal:  Tex Rep Biol Med       Date:  1969-11

5.  Preliminary report on the antimycotic effect of topical thiabendazole "in vivo".

Authors:  R Fleischmajer; J Goldstein; L Nicholas
Journal:  Curr Ther Res Clin Exp       Date:  1965-09

Review 6.  Principles in the management of oculomycosis. XXXI Edward Jackson memorial lecture.

Authors:  B R Jones
Journal:  Am J Ophthalmol       Date:  1975-05       Impact factor: 5.258

7.  Laboratory tests of antifungal drugs.

Authors:  R J Holt
Journal:  J Clin Pathol       Date:  1975-10       Impact factor: 3.411

8.  Keratochromomycosis.

Authors:  L A Wilson; R R Sexton; D Ahearn
Journal:  Arch Ophthalmol       Date:  1966-12

9.  Ocular absorption of thiabendazole-14 -C by the rabbit.

Authors:  H J Robinson; O E Graessle; E G Lehman; K L Kelley; R F Geoffroy; C Rosenblum
Journal:  Am J Ophthalmol       Date:  1966-10       Impact factor: 5.258

  9 in total
  2 in total

1.  Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution.

Authors:  Efrén Robledo-Leal; Mariana Elizondo-Zertuche; Gloria M González
Journal:  ISRN Dermatol       Date:  2012-09-13

2.  Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Authors:  Ikechukwu Okoli; Jeffrey J Coleman; Emmanouil Tampakakis; Emmanouil Tempakakis; W Frank An; Edward Holson; Florence Wagner; Annie L Conery; Jonah Larkins-Ford; Gang Wu; Andy Stern; Frederick M Ausubel; Eleftherios Mylonakis
Journal:  PLoS One       Date:  2009-09-14       Impact factor: 3.240

  2 in total

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