Literature DB >> 6765858

Suppression of nephrotoxic serum nephritis in rats by prostaglandin E1.

S L Kunkel1, M Zanetti, C Sapin.   

Abstract

The ability of specific prostaglandins to modulate the development of nephrotoxic serum nephritis (NSN) in rats has been examined. The nephrotoxicity of one intravenous injection of antibodies directed against rat glomerular basement membrane (GBM) was markedly suppressed by treatment with a stable analog of prostaglandin E1 (15-(S)-15-methyl PGE1; 15-M-PGE1). Prostaglandin E1 treatment was shown to suppress both glomerular hypercellularity and proteinuria, while the binding of specific antibody to the GBM was not altered. These studies indicate that certain prostaglandins may play an important role in the regulation of Type II immune reactions. Further investigations of the role of arachidonic acid products undoubtedly will provide valuable information regarding the modulation of tissue injury as a result of various inflammatory reactions.

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Year:  1982        PMID： 6765858      PMCID： PMC1916080     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  19 in total

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Journal:  J Immunol       Date:  1971-10       Impact factor: 5.422

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Journal:  Nature       Date:  1973-11-23       Impact factor: 49.962

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Journal:  J Immunol       Date:  1970-08       Impact factor: 5.422

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Journal:  Nature       Date:  1971-12-03       Impact factor: 49.962

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Journal:  Biochim Biophys Acta       Date:  1976-03-26

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Journal:  Arthritis Rheum       Date:  1977 Nov-Dec

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Journal:  J Exp Med       Date:  1968-01-01       Impact factor: 14.307

10.  EXPERIMENTAL GLOMERULONEPHRITIS. V. STUDIES ON THE INTERACTION OF NEPHROTOXIC ANTIBODIES WITH TISSUE OF THE RAT.

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Journal:  J Exp Med       Date:  1965-05-01       Impact factor: 14.307
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  8 in total

1.  Mechanism of prostaglandin E2 inhibition of acute changes in vascular permeability.

Authors:  K R McLeish; S R Wellhausen; G T Stelzer
Journal:  Inflammation       Date:  1987-09       Impact factor: 4.092

2.  Prostaglandin E1 suppresses macrophage infiltration and ameliorates injury in an experimental model of macrophage-dependent glomerulonephritis.

Authors:  V Cattell; J Smith; H T Cook
Journal:  Clin Exp Immunol       Date:  1990-02       Impact factor: 4.330

3.  Effects of diclofenac, indomethacin, tolfenamic acid and hydrocortisone on prostanoid production in healthy and rheumatic synovial cells.

Authors:  E Moilanen
Journal:  Agents Actions       Date:  1989-03

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Authors:  R A Stahl
Journal:  Klin Wochenschr       Date:  1986-09-15

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Authors:  H T Cook; J Smith; J A Salmon; V Cattell
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

6.  Inhibition of experimental autoimmune tubulointerstitial nephritis in Brown-Norway rats by (15S)-15-methyl prostaglandin E1. Analysis of the effect of prostaglandin E1 on the induction of the humoral immune response and the elicitation of humorally mediated inflammation.

Authors:  T R Ulich; R X Ni
Journal:  Am J Pathol       Date:  1986-08       Impact factor: 4.307

Review 7.  Prostanoids in paediatric kidney diseases.

Authors:  H W Seyberth; A Leonhardt; B Tönshoff; N Gordjani
Journal:  Pediatr Nephrol       Date:  1991-09       Impact factor: 3.714

8.  Stable analogs of prostaglandins E1 and F2 alpha ameliorate the proteinuria of aminonucleoside-of-puromycin nephrosis in Lewis rats.

Authors:  T R Ulich; J A Meline; R X Ni; M Keys; C H Wu
Journal:  Am J Pathol       Date:  1987-10       Impact factor: 4.307
  8 in total

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