Literature DB >> 6765549

Less pronounced changes in serum potassium and epinephrine during hypoglycemia induced by human insulin (recombinant DNA).

K G Petersen, K J Schlüter, L Kerp.   

Abstract

Human insulin (recombinant DNA) and purified porcine insulin were compared in healthy men. Intravenous insulin tolerance tests showed identical effects on plasma glucose when a bolus of 0.1 U/kg was injected. Following human insulin, hypokalemia and epinephrine secretion were significantly less pronounced. The differences in serum potassium concentrations are caused by a lower epinephrine response to hypoglycemia induced by human insulin in comparison to purified porcine insulin.

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Year:  1982        PMID： 6765549     DOI： 10.2337/diacare.5.2.s90

Source DB:  PubMed          Journal:  Diabetes Care        ISSN： 0149-5992            Impact factor:   19.112


  5 in total

1.  Human insulin.

Authors:  R B Tattersall; I A Macdonald
Journal:  BMJ       Date:  1989-11-25

Review 2.  Human insulin: much ado about one amino acid?

Authors:  G E Sonnenberg; M Berger
Journal:  Diabetologia       Date:  1983-12       Impact factor: 10.122

Review 3.  Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use.

Authors:  R N Brogden; R C Heel
Journal:  Drugs       Date:  1987-09       Impact factor: 9.546

4.  Counterregulatory hormone release after human and porcine insulin in healthy subjects and patients with pituitary disorders.

Authors:  M M Landgraf-Leurs; I Brügelmann; S Kammerer; R Lorenz; R Landgraf
Journal:  Klin Wochenschr       Date:  1984-07-16

5.  Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabetic patients reporting hypoglycaemia unawareness after transferring to human insulin.

Authors:  A Maran; J Lomas; H Archibald; I A Macdonald; E A Gale; S A Amiel
Journal:  BMJ       Date:  1993-01-16
  5 in total

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