Literature DB >> 6765544

Comparative study of NPH human insulin (recombinant DNA) and NPH bovine insulin in diabetic subjects.

M Marre, A Tabbi-Anneni, H Tabbi-Anneni, R Assan.   

Abstract

The hypoglycemic potencies of human insulin (recombinant DNA) and bovine NPH insulin were compared in insulin-dependent diabetic subjects. The same dosages of the two preparations were alternately injected, for two successive 5-day periods, on a twice-a-day schedule. Blood glucose profiles were monitored by finger pricking 6 times/day. Slight but significant differences in glucose time appeared, suggesting that human NPH insulin acts faster than bovine NPH, and for a shorter time.

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Year:  1982        PMID: 6765544     DOI: 10.2337/diacare.5.2.s63

Source DB:  PubMed          Journal:  Diabetes Care        ISSN: 0149-5992            Impact factor:   19.112


  2 in total

Review 1.  Human insulin. A review of its biological activity, pharmacokinetics and therapeutic use.

Authors:  R N Brogden; R C Heel
Journal:  Drugs       Date:  1987-09       Impact factor: 9.546

2.  Human (recombinant DNA) and porcine NPH insulins are unequally effective in diabetic patients. A comparative study using continuous blood glucose monitoring.

Authors:  J L Richard; M Rodier; G Cavalié; J Mirouze; L Monnier
Journal:  Acta Diabetol Lat       Date:  1984 Jul-Sep
  2 in total

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