[Treatment of carcinoma and chronology (study of time) of cancer].

Chronology of cancer is the medical science to study the time of events such as occurrence of cancer and metastasis, appearance of clinical symptom, treatment, recurrence and death of the patients, and to study the interval among these events and factors influencing them. Every patient with breast cancer has her own doubling time, which seems to be constant and independent of the site of the tumor, regardless primary or metastatic. Doubling times correlate with age of patients and the histological type of breast cancer. Among the duration of symptom, free interval and survival after recurrence, statistically significant correlation exist, and they have a close correlation with doubling times. The calculation of doubling times is not always possible in the patients with carcinoma of deeply situated organs. Among the duration of symptom, free interval and survival after recurrence of gastric cancer, however, a significant correlation has been observed. In the evaluation of the effect of anticancer treatment such as prolongation of survival time and the rate of growth should not be neglected. And the doubling time is an important factor to determine malignant characteristics of the cancer.