Literature DB >> 6763217

A clinical trial of levamisole in primary biliary cirrhosis.

S Hishon, G Tobin, P J Ciclitira.   

Abstract

A small pilot study of levamisole in primary biliary cirrhosis failed to demonstrate any improvement in liver function and immunological abnormalities even in 'early' cases. This may be due to the fact that the defect in the immune system lies in its afferent arm. At present, levamisole, which is potentially toxic, cannot be recommended in conventional doses for the treatment of this disease.

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Year:  1982        PMID： 6763217      PMCID： PMC2426569          DOI： 10.1136/pgmj.58.685.701

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  12 in total

1.  SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS.

Authors:  J G WALKER; D DONIACH; I M ROITT; S SHERLOCK
Journal:  Lancet       Date:  1965-04-17       Impact factor: 79.321

2.  Effect of steroid therapy on the clinical and laboratory features of primary biliary cirrhosis.

Authors:  C T CARMAN; J E GIANSIRACUSA
Journal:  Gastroenterology       Date:  1955-02       Impact factor: 22.682

3.  A prospective controlled trial of azathioprine in primary biliary cirrhosis.

Authors:  J Heathcote; A Ross; S Sherlock
Journal:  Gastroenterology       Date:  1976-05       Impact factor: 22.682

4.  Immunoglobulins in chronic liver disease.

Authors:  T Feizi
Journal:  Gut       Date:  1968-04       Impact factor: 23.059

5.  Impaired delayed hypersensitivity in primary biliary cirrhosis.

Authors:  S Sherlock; R A Fox; D G James; P J Scheuer; O Sharma
Journal:  Lancet       Date:  1969-05-10       Impact factor: 79.321

6.  Phytohaemagglutinin (PHA) induced lymphocyte transformation and Toxoplasma gondii antibody studies in primary biliary cirrhosis. Evidence of impaired cell-mediated immunity.

Authors:  R N MacSween; I Galbraith; M A Thomas; G Watkinson; G B Ludlam
Journal:  Clin Exp Immunol       Date:  1973-09       Impact factor: 4.330

7.  The late results of long-term treatment of primary biliary cirrhosis by corticosteroids.

Authors:  H T Howat; A J Ralston; H Varley; J A Wilson
Journal:  Rev Int Hepatol       Date:  1966

8.  Primary biliary cirrhosis.

Authors:  P Scheuer
Journal:  Proc R Soc Med       Date:  1967-12

9.  Detection of immune complexes by a new assay, the polyethylene glycol precipitation-complement consumption test (PEG-CC).

Authors:  G D Harkiss; D L Brown
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330

10.  Is primary biliary cirrhosis an immune complex disease?

Authors:  H C Thomas; B J Potter; S Sherlock
Journal:  Lancet       Date:  1977-12-17       Impact factor: 79.321
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  2 in total

1.  New directions in primary biliary cirrhosis.

Authors:  M C Bateson
Journal:  BMJ       Date:  1990-12-08

Review 2.  Pharmacological interventions for primary biliary cholangitis: an attempted network meta-analysis.

Authors:  Francesca Saffioti; Kurinchi Selvan Gurusamy; Leonardo Henry Eusebi; Emmanuel Tsochatzis; Brian R Davidson; Douglas Thorburn
Journal:  Cochrane Database Syst Rev       Date:  2017-03-28
  2 in total

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