Literature DB >> 6762960

Cloning and expression of Treponema pallidum protein antigens in Escherichia coli.

L V Stamm, P J Bassford.   

Abstract

Difficulties in culturing the bacterium Treponema pallidum have greatly hindered syphilis research. Recently, several laboratories have accomplished the expression of T. pallidum antigens in Escherichia coli. It is anticipated that treponemal antigens produced by recombinant DNA technology will provide new tools for investigating the pathogenesis and immunobiology of T. pallidum infection.

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Year:  1982        PMID： 6762960     DOI： 10.1089/dna.1982.1.329

Source DB:  PubMed          Journal:  DNA        ISSN： 0198-0238


  7 in total

1.  Cloning structural genes for Treponema pallidum immunogens and characterisation of recombinant treponemal surface protein, P2 (P2 star).

Authors:  K M Peterson; J B Baseman; J F Alderete
Journal:  Genitourin Med       Date:  1987-10

2.  Cloning and surface expression in Escherichia coli of a structural gene encoding a surface protein of Haemophilus influenzae type b.

Authors:  P L Holmans; T A Loftus; E J Hansen
Journal:  Infect Immun       Date:  1985-10       Impact factor: 3.441

3.  Identification and purification of a recombinant Treponema pallidum basic membrane protein antigen expressed in Escherichia coli.

Authors:  W S Dallas; P H Ray; J Leong; C D Benedict; L V Stamm; P J Bassford
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

4.  Identification and preliminary characterization of Treponema pallidum protein antigens expressed in Escherichia coli.

Authors:  L V Stamm; T C Kerner; V A Bankaitis; P J Bassford
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

5.  Cellular and extracellular protein antigens of Treponema pallidum synthesized during in vitro incubation of freshly extracted organisms.

Authors:  L V Stamm; P J Bassford
Journal:  Infect Immun       Date:  1985-03       Impact factor: 3.441

6.  Cloning and expression of Treponema pallidum (Nichols) antigen genes in Escherichia coli.

Authors:  M V Norgard; J N Miller
Journal:  Infect Immun       Date:  1983-11       Impact factor: 3.441

7.  Isolation of a Treponema pallidum gene encoding immunodominant outer envelope protein P6, which reacts with sera from patients at different stages of syphilis.

Authors:  K M Peterson; J B Baseman; J F Alderete
Journal:  J Exp Med       Date:  1986-10-01       Impact factor: 14.307
  7 in total

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