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Literature DB >> 6762317

Mutagenicity of methylglyoxal in coffee.

H Kasai, K Kumeno, Z Yamaizumi, S Nishimura, M Nagao, Y Fujita, T Sugimura, H Nukaya, T Kosuge.

Abstract

Major carbonyl compounds from a extract of ground roasted coffee beans were identified as 5-hydroxymethylfurfural, acetol, glyoxal, methylglyoxal and diacetyl. Among these carbonyl compounds, methylglyoxal showed considerable mutagenic activity toward Salmonella typhimurium TA100 without S9 mix (around 100,000 revertants/mg). More than 50% of the total mutagenic activity of coffee can be accounted for by the activity of methylglyoxal.

Entities: Chemical Species

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Year: 1982 PMID： 6762317

Source DB: PubMed Journal: Gan ISSN： 0016-450X

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Cited

11 in total

1. AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.

Authors: Chenfei Huang; Zhe Cao; Jun Ma; Yi Shen; Yiwen Bu; Ramina Khoshaba; Guiyuan Shi; Dan Huang; Duan-Fang Liao; Haitao Ji; Junfei Jin; Deliang Cao
Journal: Mol Carcinog Date: 2018-06-28 Impact factor: 4.784

2. Clostridium beijerinckii and Clostridium difficile detoxify methylglyoxal by a novel mechanism involving glycerol dehydrogenase.

Authors: H Liyanage; S Kashket; M Young; E R Kashket
Journal: Appl Environ Microbiol Date: 2001-05 Impact factor: 4.792

3. Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication.

Authors: Imen Ayed-Boussema; Karima Rjiba; Amal Moussa; Nourhène Mnasri; Hassen Bacha
Journal: Environ Sci Pollut Res Int Date: 2011-08-07 Impact factor: 4.223

4. Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA.

Authors: N Murata-Kamiya; H Kamiya
Journal: Nucleic Acids Res Date: 2001-08-15 Impact factor: 16.971

5. Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.

Authors: N Murata-Kamiya; H Kamiya; H Kaji; H Kasai
Journal: Nucleic Acids Res Date: 1997-05-15 Impact factor: 16.971

Mutagenicity of methylglyoxal in coffee.

1. AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.

2. Clostridium beijerinckii and Clostridium difficile detoxify methylglyoxal by a novel mechanism involving glycerol dehydrogenase.

3. Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication.

4. Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA.

5. Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.

6. Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives.

7. Mutagens in coffee and other beverages.

8. Impact of methylglyoxal and high glucose co-treatment on human mononuclear cells.

Review 9. Past, present, and future of mutagens in cooked foods.

Review 10. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer.