Literature DB >> 6761061

Metabolic effects of the triphasic oral contraceptive Trigynon.

A Vermeulen, M Thiery.   

Abstract

Effects of Trigynon, a triphase low-dose oral contraceptive, containing ethinylestradiol and l-norgestrel in various proportions, on testosterone binding globulin, transcortin, thyroxine, free testosterone, free cortisol and free thyroxine as well as on plasma lipids and glucose tolerance were studied in 12 normal women treated for 3-6 months. Trigynon appears to have dominant estrogenic effects as evidenced from the increase in transport proteins and the decrease in free testosterone concentration. Plasma lipids were not significantly influenced; glucose tolerance was slightly, but not significantly decreased.

Entities:  

Keywords:  Age Factors; Biology; Carbohydrate Metabolic Effects; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods; Dehydroepiandrosterone; Examinations And Diagnoses; Family Planning; Glucose Metabolism Effects--analysis; Glucose Tolerance Test; Laboratory Examinations And Diagnoses; Laboratory Procedures; Lipid Metabolic Effects--analysis; Lipids; Metabolic Effects; Oral Contraceptives; Oral Contraceptives, Low-dose; Physiology; Reproductive Control Agents; Steroid Metabolic Effects; Testosterone

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Year:  1982        PMID: 6761061     DOI: 10.1016/0010-7824(82)90149-4

Source DB:  PubMed          Journal:  Contraception        ISSN: 0010-7824            Impact factor:   3.375


  2 in total

1.  The relevance of the pharmacologic properties of a progestational agent to its clinical effects as a combination oral contraceptive.

Authors:  G V Upton; A Corbin
Journal:  Yale J Biol Med       Date:  1989 Sep-Oct

Review 2.  The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis.

Authors:  Y Zimmerman; M J C Eijkemans; H J T Coelingh Bennink; M A Blankenstein; B C J M Fauser
Journal:  Hum Reprod Update       Date:  2013-09-29       Impact factor: 15.610

  2 in total

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