Literature DB >> 6760957

Identification of the platelet alloantigen (PlA1) in circulating immune complexes of normal human sera.

J L Wautier, B Boizard, R Doan, J P Caen, L Hartmann.   

Abstract

An analysis of cell membrane material present in circulating immune complexes isolated from normal human sera by precipitation with polyethylene glycol (PEG) has been performed with the platelet alloantigen PlA1 and rhesus antigen used as markers. PEG precipitates obtained from the sera of subjects of known PlA1 and rhesus phenotype were resuspended in buffer and analyzed as representative of circulating immune complexes (CIC). The consumption of anti-PlA1 serum by CIC was determined by immunofluorescence and by inhibition of sodium 51chromate release from PlA1-positive target platelets. With these two techniques, PlA1 alloantigen activity was detected in CIC. This finding suggests that at least some of the cell membrane material present in CIC is derived from platelets.

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Year:  1982        PMID： 6760957     DOI： 10.1007/bf00200199

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  15 in total

1.  A new test for the detection of weak and incomplete Rh agglutinins.

Authors:  R R A COOMBS; A E MOURANT; R R RACE
Journal:  Br J Exp Pathol       Date:  1945

2.  IMMUNOREACTIONS INVOLVING PLATELETS. V. POST-TRANSFUSION PURPURA DUE TO A COMPLEMENT-FIXING ANTIBODY AGAINST A GENETICALLY CONTROLLED PLATELET ANTIGEN. A PROPOSED MECHANISM FOR THROMBOCYTOPENIA AND ITS RELEVANCE IN "AUTOIMMUNITY".

Authors:  N R Shulman; R H Aster; A Leitner; M C Hiller
Journal:  J Clin Invest       Date:  1961-09       Impact factor: 14.808

3.  C1 and human platelets. III. Role of C1 subcomponents in platelet aggregation induced by aggregated IgG.

Authors:  J L Wautier; H Souchon; L C Solal; A P Peltier; J P Caen
Journal:  Immunology       Date:  1976-10       Impact factor: 7.397

4.  Studies on the mode of reaction of the first component of complement with platelets: interaction between the collagen-like portion of C1q and platelets.

Authors:  J L Wautier; H Souchon; K B Reid; A P Peltier; J P Caen
Journal:  Immunochemistry       Date:  1977 Nov-Dec

5.  Isolation and immunologic characterization of the human platelet alloantigen, P1A1.

Authors:  T J Kunicki; R H Aster
Journal:  Mol Immunol       Date:  1979-06       Impact factor: 4.407

6.  Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol.

Authors:  M Digeon; M Laver; J Riza; J F Bach
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

Review 7.  The effects of immune complexes on blood platelets and their relationship to complement activation.

Authors:  S L Pfueller; E F Lüscher
Journal:  Immunochemistry       Date:  1972-11

8.  A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies.

Authors:  R H Aster; S E Enright
Journal:  J Clin Invest       Date:  1969-07       Impact factor: 14.808

9.  Posttransfusional immunologic thrombocytopenia. A case report.

Authors:  J P Soulier; C Patereau; N Gobert; P Achach; J Y Muller
Journal:  Vox Sang       Date:  1979       Impact factor: 2.144

10.  A simple immunofluorescence test for the detection of platelet antibodies.

Authors:  A E von dem Borne; F W Verheugt; F Oosterhof; E von Riesz; A B de la Rivière; C P Engelfriet
Journal:  Br J Haematol       Date:  1978-06       Impact factor: 6.998
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