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Literature DB >> 6760861

Selective uptake of alloxan by pancreatic B-cells.

Abstract

Alloxan rapidly binds to or accumulates in pancreatic B-cells as distinct from non-B-cells. The selective uptake of this cytotoxic agent by the insulin-producing B-cells might account for its well-known diabetogenic effect.

Entities: Chemical

Mesh：

Substances：
Alloxan

Year: 1982 PMID： 6760861 PMCID： PMC1153992 DOI： 10.1042/bj2080513

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Effect of alloxan on islet tissue permeability: protection and reversal by sugars.

Authors: D Watkins; S J Cooperstein; A Lazarow
Journal: Am J Physiol Date: 1973-03

2. Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors: P E Lacy; M Kostianovsky
Journal: Diabetes Date: 1967-01 Impact factor: 9.461

3. A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat islets.

Authors: D G Pipeleers; M A Pipeleers-Marichal
Journal: Diabetologia Date: 1981-06 Impact factor: 10.122

4. Effect of alloxan on permeability and hexose transport in rat pancreatic islets.

Authors: M L McDaniel; S Anderson; J Fink; C Roth; P E Lacy
Journal: Endocrinology Date: 1975-07 Impact factor: 4.736

5. Islet cell analysis and purification by light scatter and autofluorescence.

Authors: M Van de Winkle; E Maes; D Pipeleers
Journal: Biochem Biophys Res Commun Date: 1982-07-30 Impact factor: 3.575

6. Superoxide dismutase is a prophylactic against alloxan diabetes.

Authors: K Grankvist; S Marklund; I B Täljedal
Journal: Nature Date: 1981-11-12 Impact factor: 49.962

7. Evidence for mediated transport of glucose in mammalian pancreatic -cells.

Authors: B Hellman; J Sehlin; I B Täljedal
Journal: Biochim Biophys Acta Date: 1971-07-06

8. Alloxan uptake by isolated rat islets of Langerhans.

Authors: D C Weaver; M L McDaniel; P E Lacy
Journal: Endocrinology Date: 1978-06 Impact factor: 4.736

9. Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.

Authors: K Grankvist; S Marklund; J Sehlin; I B Täljedal
Journal: Biochem J Date: 1979-07-15 Impact factor: 3.857

10. Determinants of the selective toxicity of alloxan to the pancreatic B cell.

Authors: W J Malaisse; F Malaisse-Lagae; A Sener; D G Pipeleers
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

18 in total

1. Central administration of alloxan impairs glucose tolerance in rats.

Authors: M Salkovic-Petrisic; Z Lackovic; S Hoyer; P Riederer
Journal: J Neural Transm (Vienna) Date: 2005-10 Impact factor: 3.575

Review 2. Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects.

Authors: Lucas F Gushiken; Fernando P Beserra; Ariane L Rozza; Patrícia L Bérgamo; Danilo A Bérgamo; Cláudia H Pellizzon
Journal: Rev Diabet Stud Date: 2016-08-10

3. Effects of dehydrouramil on protein phosphorylation and insulin secretion in rat islets of Langerhans.

Authors: D E Harrison; M Poje; B Rocic; S J Ashcroft
Journal: Biochem J Date: 1986-07-01 Impact factor: 3.857

4. Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.

Authors: G Drews; C Krämer; M Düfer; P Krippeit-Drews
Journal: Biochem J Date: 2000-12-01 Impact factor: 3.857

5. α-Amylase and α-glucosidase inhibitor effects and pancreatic response to diabetes mellitus on Wistar rats of Ephedra alata areal part decoction with immunohistochemical analyses.

Authors: Jihene Ben Lamine; Mouhamed Ali Boujbiha; Sabra Dahane; Amal Ben Cherifa; Aida Khlifi; Hassiba Chahdoura; Mouhamed Taher Yakoubi; Salima Ferchichi; Nacer El Ayeb; Lotfi Achour
Journal: Environ Sci Pollut Res Int Date: 2019-02-07 Impact factor: 4.223

6. Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro.

Authors: S Sandler; I Swenne
Journal: Diabetologia Date: 1983-11 Impact factor: 10.122

7. Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.

Authors: M Kullin; Z Li; J Bondo Hansen; N Welsh; F A Karlsson; S Sandler
Journal: Diabetologia Date: 2003-01-11 Impact factor: 10.122