Literature DB >> 6759176

Phosphorylation--dephosphorylation of purified insulin receptor from human placenta. Effect of insulin.

F Machicao, T Urumow, O H Wieland.   

Abstract

The insulin receptor of human placenta even after extensive purification is phosphorylated in the presence of [gamma-32P]ATP and NaF, and is dephosphorylated again on incubation in NaF-free medium. Insulin stimulates phosphate incorporation into the Mr 95 000 subunit probably by activation of the phosphorylation step. Our data suggest that the insulin receptor contains both kinase and phosphatase activities that may control the phosphorylation state of the receptor.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6759176     DOI： 10.1016/0014-5793(82)81079-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta.

Authors:  F Machicao; H Häring; M F White; J M Carrascosa; B Obermaier; O H Wieland
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

2.  Evidence that insulin and guanosine triphosphate regulate dephosphorylation of the beta-subunit of the insulin receptor in sarcolemma membranes isolated from skeletal muscle.

Authors:  R S Horn; E Lystad; A Adler; O Walaas
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857

3.  Influence of a small molecular weight proteinase inhibitor, gabexate mesilate (FOY), on insulin receptor function in vitro.

Authors:  R Göke; B Göke; H J Steinfelder; R Arnold
Journal:  Int J Pancreatol       Date:  1988-03

4.  Identification of the alpha beta monomer of the adipocyte insulin receptor by insulin binding and autophosphorylation.

Authors:  G Velicelebi; R A Aiyer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

5.  Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity, but not of receptor endocytosis.

Authors:  A D Blake; N S Hayes; E E Slater; C D Strader
Journal:  Biochem J       Date:  1987-07-15       Impact factor: 3.857

6.  Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes.

Authors:  B Obermaier; B Ermel; D Kirsch; J Mushack; E Rattenhuber; E Biemer; F Machicao; H U Häring
Journal:  Diabetologia       Date:  1987-02       Impact factor: 10.122

7.  Studies on insulin-stimulated phosphorylation of acetyl-CoA carboxylase, ATP citrate lyase and other proteins in rat epididymal adipose tissue. Evidence for activation of a cyclic AMP-independent protein kinase.

Authors:  R W Brownsey; N J Edgell; T J Hopkirk; R M Denton
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

8.  Effects of exogenous insulin on placental transfer of maternal glucose to the rat fetus.

Authors:  X Testar; M A Lasunción; R Chieri; E Herrera
Journal:  Diabetologia       Date:  1985-10       Impact factor: 10.122

9.  Tyrosine kinase activity of insulin receptors from human placenta. Effects of autophosphorylation and cyclic AMP-dependent protein kinase.

Authors:  H G Joost; H J Steinfelder; C Schmitz-Salue
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857

10.  Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

Authors:  M Kasuga; Y Fujita-Yamaguchi; D L Blithe; C R Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.