Literature DB >> 6758907

Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle.

A Bennett, G J Sanger.   

Abstract

1 Pinane thromboxane A2 (PTxA2) and its epi-OH isomer were studied on rat and human stomach longitudinal muscle. 2 PTxA2 (0.5 micrograms/ml) usually caused a slight contraction of rat gastric fundus. Contractions to PGE2, PGF2 alpha, PGI2 and epoxymethano analogues of PGH2 (U-46619 and U-44069) were substantially inhibited, whereas those to PGD2 and acetylcholine were only slightly reduced. 3 In human stomach, PTxA2 0.5 micrograms/ml rarely stimulated the muscle. Contractions to PGE2, PGF2 alpha and U-46619 were antagonized, with little effect on those to acetylcholine. 4 epi-PTxA2 (0.5 micrograms/ml) did not affect rat gastric tone. It was moderately potent against PGI2 on rat gastric fundus, but was less effective than PTxA2 against U-44069.

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Year:  1982        PMID： 6758907      PMCID： PMC2044671          DOI： 10.1111/j.1476-5381.1982.tb09336.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  Prostaglandin E antagonist activity of 11, 15-bisdeoxy prostaglandin E1 and congeners.

Authors:  E L Tolman; R Partridge; E T Barris
Journal:  Prostaglandins       Date:  1977-07

Review 2.  Prostaglandin antagonists.

Authors:  A Bennett
Journal:  Adv Drug Res       Date:  1974

3.  Prostaglandin antagonists: synthesis and smooth muscle activity.

Authors:  J Fried; T S Santhanakrishnan; J Himizu; C H Lin; S H Ford; B Rubin; E O Grigas
Journal:  Nature       Date:  1969-07-12       Impact factor: 49.962

4.  Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation.

Authors:  K C Nicolaou; R L Magolda; J B Smith; D Aharony; E F Smith; A M Lefer
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

5.  Pinane thromboxane A2: a TXA2 antagonist with antithrombotic properties.

Authors:  D Aharony; J B Smith; E F Smith; A M Lefer; R L Magolda; K D Nicolaou
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

6.  U-46619, a selective thromboxane A2-like agonist? [proceedings].

Authors:  R A Coleman; P P Humphrey; I Kennedy; G P Levy; P Lumley
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739

7.  A structural analog of thromboxane A2.

Authors:  M F Ansell; M P Caton; M N Palfreyman; K A Stuttle; D Tuffin; J L Walker
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

8.  Prostaglandin E antagonist activity of 11-deoxy-16,16-trimethyleneprostaglandin E1.

Authors:  J E Birnbaum; E L Tolman
Journal:  Prostaglandins       Date:  1979-09

9.  13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.

Authors:  G C Le Breton; D L Venton; S E Enke; P V Halushka
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

10.  Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2.

Authors:  A M Lefer; E F Smith; H Araki; J B Smith; D Aharony; D A Claremon; R L Magolda; K C Nicolaou
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205
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  4 in total

1.  Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets.

Authors:  S Hamid-Bloomfield; B J Whittle
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

2.  Involvement of thromboxane a(2) in the modulation of pacemaker activity of interstitial cells of cajal of mouse intestine.

Authors:  Jin Ho Kim; Soo Jin Choi; Cheol Ho Yeum; Pyung Jin Yoon; Seok Choi; Jae Yeoul Jun
Journal:  Korean J Physiol Pharmacol       Date:  2008-02-28       Impact factor: 2.016

3.  Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors.

Authors:  Y Okada; A Hara; H Ma; C Y Xiao; O Takahata; Y Kohgo; S Narumiya; F Ushikubi
Journal:  Br J Pharmacol       Date:  2000-10       Impact factor: 8.739

4.  Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor-dependent contractions of guinea pig gastric fundus smooth muscle.

Authors:  Keyue Xu; Miyuki Shimizu; Chika Murai; Miki Fujisawa; Daichi Ito; Noboru Saitoh; Yutaka Nakagome; Mio Yamashita; Azusa Murata; Shunya Oikawa; Guanghan Ou; Kento Yoshioka; Keisuke Obara; Yoshio Tanaka
Journal:  Pharmacol Res Perspect       Date:  2022-06
  4 in total

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