Literature DB >> 6758273

Treatment of infected urinary stones in rats by a new hydroxamic acid, "N-(pivaloyl)glycinohydroxamic acid.

H Takeuchi, Y Okada, K Kobashi, O Yoshida.   

Abstract

The effectiveness of a new urease inhibitor, N-(pivaloyl)glycinohydroxamic acid, in the treatment of infected urinary stones was investigated. The hydroxamic acid markedly inhibited and alkalinisation of urine and stone formation when it was administered orally to rats with urinary tract infection caused by Proteus mirabilis; its inhibitory effect was potentiated by concomitant treatment with Cephalexin. This compound may become a useful medicine for the treatment of struvite stones.

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Year:  1982        PMID： 6758273     DOI： 10.1007/bf00255948

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  11 in total

1.  Specific inhibition of urease by hydroxamic acids.

Authors:  K KOBASHI; J HASE; K UEHARA
Journal:  Biochim Biophys Acta       Date:  1962-12-04

2.  Experimental urolithiasis. VIII. Furadantin in treatment of experimental proteus infection with stone formation.

Authors:  C W VERMEULEN; R GOETZ
Journal:  J Urol       Date:  1954-08       Impact factor: 7.450

3.  A new method of determination of hydroxamic acid by its urease inhibition and application to biochemical studies.

Authors:  K Kobashi; N Terashima; S Takebe; J Hase
Journal:  J Biochem       Date:  1978-01       Impact factor: 3.387

4.  Adjunctive chemotherapy of infection-induced staghorn calculi.

Authors:  D P Griffith; P A Moskowitz; C E Carlton
Journal:  J Urol       Date:  1979-06       Impact factor: 7.450

5.  Inhibition of Proteus vulgaris urease by hydroxamic acids.

Authors:  J Hase; K Kobashi
Journal:  J Biochem       Date:  1967-09       Impact factor: 3.387

6.  Prevention of infected urinary stones in rats by urease inhibitor: a new hydroxamic acid derivative.

Authors:  H Takeuchi; K Kobashi; O Yoshida
Journal:  Invest Urol       Date:  1980-09

7.  Benurestat, a urease inhibitor for the therapy of infected ureolysis.

Authors:  J A Andersen
Journal:  Invest Urol       Date:  1975-03

8.  Interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria.

Authors:  D M Musher; C Saenz; D P Griffith
Journal:  Antimicrob Agents Chemother       Date:  1974-02       Impact factor: 5.191

9.  Therapy for urolithiasis by hydroxamic acids. III. Urease inhibitory potency and urinary excretion rate of N-acylglycinohydroxamic acids.

Authors:  K Munakata; K Kobashi; S Takebe; J Hase
Journal:  J Pharmacobiodyn       Date:  1980-09

10.  Mutagenicity of N-acylglycinohydroxamic acids and related compounds.

Authors:  K Munakata; H Mochida; S Kondo; Y Suzuki
Journal:  J Pharmacobiodyn       Date:  1980-11
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  1 in total

1.  Stone formation by Ureaplasma urealyticum in human urine and its prevention by urease inhibitors.

Authors:  S Takebe; A Numata; K Kobashi
Journal:  J Clin Microbiol       Date:  1984-11       Impact factor: 5.948
  1 in total

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