Literature DB >> 6756497

Characterization of two insulin-binding components of rat-liver plasma membranes.

M D Baron, P H Sönksen.   

Abstract

We have identified and isolated two forms of insulin receptor from rat-liver plasma membranes. The smaller (Mr = 90k) is a single polypeptide. The same polypeptide appears to be the insulin-binding site of the larger Mr = 280k). Only the larger, multisubunit, receptor shows high-affinity binding of insulin and negative cooperativity in its dissociation kinetics.

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Year:  1982        PMID： 6756497     DOI： 10.1007/bf01114938

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  8 in total

1.  Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor.

Authors:  M A Soos; K Siddle; M D Baron; J M Heward; J P Luzio; J Bellatin; E S Lennox
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

2.  Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor.

Authors:  C C Wang; I D Goldfine; Y Fujita-Yamaguchi; H G Gattner; D Brandenburg; P De Meyts
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

3.  Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells.

Authors:  M A Soos; J Whittaker; R Lammers; A Ullrich; K Siddle
Journal:  Biochem J       Date:  1990-09-01       Impact factor: 3.857

4.  Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor.

Authors:  E J Pierce; M D Davison; R G Parton; W H Habig; D R Critchley
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

5.  A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors.

Authors:  R H Ganderton; K K Stanley; C E Field; M P Coghlan; M A Soos; K Siddle
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

Review 6.  The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

Authors:  P De Meyts
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

7.  Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors.

Authors:  M A Soos; K Siddle
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

8.  Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules.

Authors:  R M O'Brien; M A Soos; K Siddle
Journal:  EMBO J       Date:  1987-12-20       Impact factor: 11.598
  8 in total

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