[Pulsatile treatment with gonadotropin-releasing hormone (Gn-RH)].

In this review an account is made on the physiological and pathophysiological basis as well as on the clinical results of chronic-intermittent (pulsatile) administration of Gn-RH in the treatment of infertility in hypothalamic amenorrhea. Hypothalamic amenorrhea is considered to be the result of a deficient hypothalamic secretion of Gn-RH, which is a prerequisite of normal pituitary gonadotropic function, deficient endogenous Gn-RH is replaced. An adequate dose of Gn-RH provided, which takes into account the degree of impairment of hypothalamic function in the individual case, follicular maturation, ovulation and corpus luteum formation are achieved in nearly every treatment cycle. The conception rate, which is, in addition to the treated dysfunction, also dependent upon other factors, is remarkably high as well.