Literature DB >> 6751637

Improved leucocyte migration inhibition response of leucocytes from lepromatous leprosy patients with hapten modified M. leprae.

A Fotedar, A S Mustafa, B S Narang, G P Talwar.   

Abstract

Two acetoacetylated derivatives of Mycobacterium leprae with variable hapten groups and a conjugate with tetanus toxoid were prepared. These were tested as antigens along with unmodified M. leprae in the leucocyte migration inhibition response of leucocytes from clinically, bacteriologically and histopathologically confirmed cases of lepromatous leprosy. LMI response was poor with M. leprae, but was significantly enhanced with acetoacetylated M. leprae.

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Year:  1982        PMID： 6751637      PMCID： PMC1536491     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  25 in total

1.  The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

Authors:  N A Mitchison
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

Review 2.  The biological activities of soluble lymphocyte products.

Authors:  E Pick; J L Turk
Journal:  Clin Exp Immunol       Date:  1972-01       Impact factor: 4.330

3.  Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

Authors:  J R David
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

4.  Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.

Authors:  W E Bullock; P Fasal
Journal:  J Immunol       Date:  1971-04       Impact factor: 5.422

5.  Tolerance induction by an apparently non-immunogenic molecule.

Authors:  G E Roelants; J W Goodman
Journal:  Nature       Date:  1970-07-11       Impact factor: 49.962

6.  Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes.

Authors:  T Godal; B Myklestad; D R Samuel; B Myrvang
Journal:  Clin Exp Immunol       Date:  1971-12       Impact factor: 4.330

Review 7.  Immunological phenomena in leprosy and related diseases.

Authors:  J L Turk; A D Bryceson
Journal:  Adv Immunol       Date:  1971       Impact factor: 3.543

8.  Classification of leprosy according to immunity. A five-group system.

Authors:  D S Ridley; W H Jopling
Journal:  Int J Lepr Other Mycobact Dis       Date:  1966 Jul-Sep

9.  Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

Authors:  B R Bloom; B Bennett
Journal:  Science       Date:  1966-07-01       Impact factor: 47.728

10.  The production of thyroiditis and antibody following injection of unaltered thyroglobulin without adjuvant into rabbits previously stimulated with altered thyroglobulin.

Authors:  W O Weigle
Journal:  J Exp Med       Date:  1965-12-01       Impact factor: 14.307
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