Duration of intradermal anaesthesia with mixtures of bupivacaine and lidocaine.

In a double-blind trial on 20 human volunteers, the duration of intradermal anaesthesia with bupivacaine 0.25 per cent was compared with duration with a mixture of bupivacaine 0.25 per cent and carbonated lidocaine 1.0 per cent and with a mixture of bupivacaine 0.25 per cent and lidocaine hydrochloride 1.0 per cent. The duration of intradermal anaesthesia produced by bupivacaine mixed with carbonated lidocaine was 114 +/- 56 (mean +/- 1 SD) minutes and was not significantly shorter than the duration of the bupivacaine alone, at 125 +/- 70 minutes, or duration with the mixture of bupivacaine and lidocaine hydrochloride, which was 112 +/- 41 minutes. These results indicate that the mixture of bupivacaine with either carbonated lidocaine or lidocaine hydrochloride may be used for local anaesthesia without significant shortening of the duration of action.

RCT Entities:   Population Interventions Outcomes