| Literature DB >> 6750791 |
E E Montamat, C Burgos, N M Gerez de Burgos, L E Rovai, A Blanco, E L Segura.
Abstract
Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.Entities:
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Year: 1982 PMID： 6750791 DOI： 10.1126/science.6750791
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728