| Literature DB >> 6750790 |
M B Nekola, A Horvath, L J Ge, D H Coy, A V Schally.
Abstract
A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.Entities:
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Year: 1982 PMID： 6750790 DOI： 10.1126/science.6750790
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728