Literature DB >> 6750108

Inhibition by PGI-2 of myometrial activity in vivo in non-pregnant ovariectomized sheep.

S J Lye, J R Challis.   

Abstract

The effects of PGI-salt and PGI-2 methyl ester on intrauterine pressure (IUP) and uterine electromyographic activity (EMG) were examined in vivo in non-pregnant ovariectomized sheep. PGI-2 salt and PGI-2 methyl ester (50--200 micrograms) reduced significantly the frequency and amplitude of IUP cycles and also inhibited the associated uterine EMG activity. Injections of oxytocin (50 mU) or PGF-2 alpha (2 micrograms) partly overcame the inhibiton of IUP induced by the PGI-2 methyl ester. These results suggest that endogenous PGI-2 may be involved in the regulation of uterine activity in sheep.

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Year:  1982        PMID： 6750108     DOI： 10.1530/jrf.0.0660311

Source DB:  PubMed          Journal:  J Reprod Fertil        ISSN： 0022-4251


  4 in total

1.  Effects of progesterone treatment on expression of genes involved in uterine quiescence.

Authors:  Melvyn S Soloff; Yow-Jiun Jeng; Michael G Izban; Mala Sinha; Bruce A Luxon; Susan J Stamnes; Sarah K England
Journal:  Reprod Sci       Date:  2011-08       Impact factor: 3.060

2.  Despite a massive increase in cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis. A paradox?

Authors:  M L Casey; P C MacDonald; M D Mitchell
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

3.  Maintenance and characterization of human myometrial smooth muscle cells in monolayer culture.

Authors:  M L Casey; P C MacDonald; M D Mitchell; J M Snyder
Journal:  In Vitro       Date:  1984-05

4.  In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium.

Authors:  J Senior; R Sangha; G S Baxter; K Marshall; J K Clayton
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739
  4 in total

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