[Effect of myocardial ischemia on adenine nucleotide metabolism].

Patients with coronary heart disease (CHD), neurocirculatory dystonia and acute myocardial infarction showed statistically significant, positive linear correlations between the levels of inosine and hypoxanthine as well as the total concentration in the arterial blood and the blood from the coronary sinus. The correlation analysis ascertained that CHD patients in the initial state exhibited a considerable extraction of inosine by the myocardium as compared to patients with neurocirculatory dystonia and that in electrically stimulated ischemia it was sharply reduced. Electrostimulation in the group of patients with neurocirculatory dystonia had no effect on the rate of inosine extraction. Acute myocardial infarction was related to a higher rate of inosine extraction and to inosine production in the myocardium, the latter being explained by the degradation of adenyl nucleotides in conditions of acute ischemia. It is outlined that the total level of inosine and hypoxanthine in the arterial blood of patients with acute myocardial infarction may indicate the severity of infarction while its variations over time may be prognostically valuable.