| Literature DB >> 6748156 |
P Delatour, F Garnier, E Benoit, C Longin.
Abstract
The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole. In the rat, the metabolic inhibitor, SKF-525A, induced changes in embryotoxicity which were well correlated with plasma levels of identified embryotoxic metabolites, but not with the levels of foetal tissue bound drug metabolites.Entities:
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Year: 1984 PMID： 6748156 DOI： 10.1111/j.1365-2885.1984.tb00890.x
Source DB: PubMed Journal: J Vet Pharmacol Ther ISSN： 0140-7783 Impact factor: 1.786