| Literature DB >> 6747650 |
P A Barford, J A Blair, C Eggar, C Hamon, C Morar, S B Whitburn.
Abstract
There is a defect in tetrahydrobiopterin metabolism in brains from subjects with senile dementia of Alzheimer type compared to age-matched controls. This defect results in lowered total biopterin concentrations in brain. Brains from subjects with senile dementia of Alzheimer type retain their ability to synthesis neopterin and have normal dihydropteridine reductase activity, indicating a specific loss of ability to convert dihydroneopterin triphosphate to tetrahydrobiopterin.Entities:
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Year: 1984 PMID： 6747650 PMCID： PMC1027905 DOI： 10.1136/jnnp.47.7.736
Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154