Literature DB >> 6746708

Contamination of toiletries and cosmetic products with volatile and nonvolatile N-nitroso carcinogens.

B Spiegelhalder, R Preussmann.   

Abstract

Commercially available cosmetics and toiletries were analyzed for contamination with volatile and nonvolatile N-nitrosamines. Of a total of 145 samples analyzed 50 were found to contain N-nitrosodimethylamine (max. value found 24 micrograms/kg), 26 samples were contaminated with N-nitrosomorpholine (max. value found 640 micrograms/kg), and 25 samples contained N-nitrosodiethanolamine, a non-volatile carcinogen (max. value found 1400 micrograms/kg). These results are discussed and compared with other published data on NDE1A in cosmetics, with reference to potential human exposure and to possible preventive measures.

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Year:  1984        PMID: 6746708     DOI: 10.1007/BF00390990

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN: 0171-5216            Impact factor:   4.553


  14 in total

1.  II.6.b Analysis of cosmetics, cutting fluids and other products containing detergents, surfactants and amines.

Authors:  B Spiegelhalder; R Preussmann
Journal:  IARC Sci Publ       Date:  1983

2.  II.4.b Determination of volatile nitrosamines in food, animal feed and other biological materials by low-temperature vacuum distillation and chemiluminescence detection.

Authors:  G Eisenbrand; G Ellen; R Preussmann; P L Schuller; B Spiegelhalder; R W Stephany; K S Webb
Journal:  IARC Sci Publ       Date:  1983

3.  Primary amine use and other strategies for preventing human exposure to N nitroso compounds: application to cutting fluids.

Authors:  L K Keefer; T J Hansen
Journal:  IARC Sci Publ       Date:  1982

4.  In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics.

Authors:  F N Marzulli; D M Anjo; H I Maibach
Journal:  Food Cosmet Toxicol       Date:  1981-12

5.  Urinary excretion of N-nitrosodiethanolamine in rats following its epicutaneous and intratracheal administration and its formation in vivo following skin application of diethanolamine.

Authors:  R Preussmann; B Spiegelhalder; G Eisenbrand; G Würtele; I Hofmann
Journal:  Cancer Lett       Date:  1981-08       Impact factor: 8.679

6.  [Analysis of nitrosodiethanolamine in the products of cosmetic industry].

Authors:  D Klein; A M Girard; J de Smedt; Y Fellion; G Debry
Journal:  Food Cosmet Toxicol       Date:  1981-04

7.  N-Nitrosodiethanolamine in cosmetics, lotions and shampoos.

Authors:  T Y Fan; U Goff; L Song; D H Fine; G P Arsenault; K Biemann
Journal:  Food Cosmet Toxicol       Date:  1977-10

8.  Urinary excretion of N-nitrosamines in rats and humans.

Authors:  B Spiegelhalder; G Eisenbrand; R Preussmann
Journal:  IARC Sci Publ       Date:  1982

9.  Penetration of rat skin by N-nitrosodiethanolamine and N-nitrosomorpholine.

Authors:  W Lijinsky; A M Losikoff; E B Sansone
Journal:  J Natl Cancer Inst       Date:  1981-01       Impact factor: 13.506

10.  N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products.

Authors:  S S Hecht; J B Morrison; J A Wenninger
Journal:  Food Chem Toxicol       Date:  1982-04       Impact factor: 6.023

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  7 in total

1.  Theoretical investigation of reactivities of amines in the N-nitrosation reactions by N2O3.

Authors:  Zhi Sun; Yong Dong Liu; Rugang Zhong
Journal:  J Mol Model       Date:  2010-06-06       Impact factor: 1.810

2.  Increased mutagenicity of N-nitrosodiethanolamine in human lymphocyte cultures after activation by alcohol dehydrogenase.

Authors:  I Henn; G Eisenbrand; H Zankl
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

Review 3.  Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed.

Authors:  Yupeng Li; Stephen S Hecht
Journal:  Int J Mol Sci       Date:  2022-04-20       Impact factor: 6.208

4.  Trapping of a cross-link formed by a major purine adduct of a metabolite of the carcinogen N-nitrosomorpholine by inorganic and biological reductants.

Authors:  Niangoran Koissi; James C Fishbein
Journal:  Chem Res Toxicol       Date:  2013-05-02       Impact factor: 3.739

5.  Proline is not useful as a chemical probe to measure nitrosation in the gastrointestinal tract of patients with gastric disorders characterised by anacidic conditions.

Authors:  B Adam; P Schlag; P Friedl; R Preussmann; G Eisenbrand
Journal:  Gut       Date:  1989-08       Impact factor: 23.059

6.  N-nitrosodiethanolamine is activated in the rat to an ultimate genotoxic metabolite by sulfotransferase.

Authors:  W Sterzel; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

7.  Cytogenetic effects of N-nitrosodiethanolamine (NDELA) and NDELA-monoacetate in human lymphocytes.

Authors:  U Dittberner; G Eisenbrand; H Zankl
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

  7 in total

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