Literature DB >> 6745938

Estimating the recombination frequency for the PTC-Kell linkage.

M Anne-Spence, C T Falk, K Neiswanger, L L Field, M L Marazita, F H Allen, R M Siervogel, A F Roche, B F Crandall, R S Sparkes.   

Abstract

Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of theta was 0.05. These two new data sets give a combined maximum likelihood estimate of theta m = f = 0.28. Estimating the recombination frequency for the sexes separately gave theta m = 0.29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies.

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Year:  1984        PMID： 6745938     DOI： 10.1007/BF00272997

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  PTC TASTE SENSITIVITY AND ENDEMIC GOITER IN BRAZIL.

Authors:  E AZEVEDO; H KRIEGER; M P MI; N E MORTON
Journal:  Am J Hum Genet       Date:  1965-01       Impact factor: 11.025

2.  Taste sensitivity to PTC in 60 Norwegian families with 176 children; confirmation of the hypothesis of single gene inheritance.

Authors:  B BRANDTZAEG MERTON
Journal:  Acta Genet Stat Med       Date:  1958

3.  The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1956-06       Impact factor: 11.025

4.  Sequential tests for the detection of linkage.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

5.  Linkage relations of the loci for Kell and phenylthiocarbamide taste sensitivity.

Authors:  P M Conneally; M Dumont-Driscoll; R S Huntzinger; W E Nance; C E Jackson
Journal:  Hum Hered       Date:  1976       Impact factor: 0.444

6.  Probable genetic linkage between autosomal dominant retinitis pigmentosa (RP) and amylase (AMY2): evidence of an RP locus on chromosome 1.

Authors:  M A Spence; R S Sparkes; J R Heckenlively; J T Pearlman; D Zedalis; M Sparkes; M Crist; S Tideman
Journal:  Am J Hum Genet       Date:  1977-07       Impact factor: 11.025

7.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

8.  Linkage relations of the phenylthiocarbamide locus (PTC).

Authors:  B F Crandall; M A Spence
Journal:  Hum Hered       Date:  1974       Impact factor: 0.444

9.  Linkage relationships between 22 autosomal markers.

Authors:  E A Chautard-Freire-Maia
Journal:  Ann Hum Genet       Date:  1974-10       Impact factor: 1.670

10.  Genetics of blood groups. Linkage analysis of 207 pedigrees.

Authors:  I Umansky; J Reid; P A Corcoran; D Bolling; J Schulze; J H Renwick; C F Moorrees; F H Allen
Journal:  Vox Sang       Date:  1966 Jul-Aug       Impact factor: 2.144
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  3 in total

1.  Phenylthiocarbamide: a 75-year adventure in genetics and natural selection.

Authors:  Stephen Wooding
Journal:  Genetics       Date:  2006-04       Impact factor: 4.562

2.  Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p.

Authors:  Dennis Drayna; Hilary Coon; Un-Kyung Kim; Tami Elsner; Kevin Cromer; Brith Otterud; Lisa Baird; Andy P Peiffer; Mark Leppert
Journal:  Hum Genet       Date:  2003-03-06       Impact factor: 4.132

Review 3.  The genetics of phenylthiocarbamide perception.

Authors:  S W Guo; D R Reed
Journal:  Ann Hum Biol       Date:  2001 Mar-Apr       Impact factor: 1.533
  3 in total

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