Literature DB >> 6745435

Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability.

K Harano, T Harano, S Shibata, S Ueda, H Mori, M Seki.   

Abstract

A new abnormal hemoglobin, Hb Okazaki [beta 93(F9) Cys----Arg], with an amino acid substitution at the tyrosine pocket of the beta chain as well as at the alpha 2 beta 1 contact of the quaternary structure of molecule, was discovered in a Japanese man. This hemoglobin showed increased oxygen affinity and molecular instability.

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Year:  1984        PMID: 6745435     DOI: 10.1016/0014-5793(84)81014-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  2 in total

1.  Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

Authors:  C A Head; C Brugnara; R Martinez-Ruiz; R M Kacmarek; K R Bridges; D Kuter; K D Bloch; W M Zapol
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

2.  Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin.

Authors:  Karin Kettisen; Michael Brad Strader; Francine Wood; Abdu I Alayash; Leif Bülow
Journal:  Redox Biol       Date:  2018-08-22       Impact factor: 11.799

  2 in total

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