Literature DB >> 6745305

Pharmacokinetics and tissue localization of doxycycline polyphosphate and doxycycline hydrochloride in the rat.

G Michel, J Mosser, J Olle.   

Abstract

Two doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay. Only an insignificant fraction of the antibiotics was found to cross the blood brain barrier. Doxycycline was highly concentrated in excretory organs: liver, kidneys and caecum. The high intestinal drug level observed is probably related to the entero-hepatic cycle of this antibiotic. There was a good correlation between serum and heart doxycycline concentration; heart level was about twice that of serum. In lung, antibiotic level was always higher than in serum.

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Year:  1984        PMID： 6745305     DOI： 10.1007/BF03189618

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  17 in total

1.  The excretion and distribution in body fluids of tetracyclines after intravenous administration to dogs.

Authors:  M von WITTENAU; R YEARY
Journal:  J Pharmacol Exp Ther       Date:  1963-05       Impact factor: 4.030

2.  Theory and practical impact of binding of antimicrobials to serum proteins and tissue.

Authors:  W A Craig; B Suh
Journal:  Scand J Infect Dis Suppl       Date:  1978

3.  Doxycycline pharmacokinetics in the absence of renal function.

Authors:  A Whelton; M Schach von Wittenau; T M Twomey; W G Walker; J R Bianchine
Journal:  Kidney Int       Date:  1974-05       Impact factor: 10.612

4.  Simplified, accurate method for antibiotic assay of clinical specimens.

Authors:  J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal:  Appl Microbiol       Date:  1966-03

5.  [Structure-activity correlations in the tetracycline family].

Authors:  J B Fourtillan; M A Lefèbvre
Journal:  Nouv Presse Med       Date:  1980-01-10

6.  [Pharmacokinetic study of doxycycline in man by high performance liquid chromatography. Administration of single 200 mg doses intravenously and orally].

Authors:  J B Fourtillan; M A Lefebvre; M C Saux; B Becq-Giraudon
Journal:  Nouv Presse Med       Date:  1980-01-10

7.  [Use of tetracyclines during renal failure].

Authors:  A Whelton
Journal:  Nouv Presse Med       Date:  1980-01-10

8.  The disposition of doxycycline by the rat.

Authors:  M Schach VON WITTENAU; M Schachaavonwittenau; T M Twomey; A C Swindell
Journal:  Chemotherapy       Date:  1972       Impact factor: 2.544

Review 9.  Doxycycline in serum and bronchial secretions.

Authors:  B J Hartnett; G E Marlin
Journal:  Thorax       Date:  1976-04       Impact factor: 9.139

10.  Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects.

Authors:  P G Welling; P A Koch; C C Lau; W A Craig
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191
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  5 in total

Review 1.  Clinical pharmacokinetics of doxycycline and minocycline.

Authors:  S Saivin; G Houin
Journal:  Clin Pharmacokinet       Date:  1988-12       Impact factor: 6.447

2.  A Sox10(rtTA/+) Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear.

Authors:  Bradley J Walters; Jian Zuo
Journal:  J Assoc Res Otolaryngol       Date:  2015-04-21

3.  Inducible expression of phospholipid transfer protein (PLTP) in transgenic mice: acute effects of PLTP on lipoprotein metabolism.

Authors:  Matthijs Moerland; Nora Anghelescu; Hannelore Samyn; Rien van Haperen; Teus van Gent; John Strouboulis; Arie van Tol; Frank Grosveld; Rini de Crom
Journal:  Transgenic Res       Date:  2007-04-17       Impact factor: 2.788

4.  Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms.

Authors:  Prashant S Dalvi; Anil Singh; Hiren R Trivedi; Feroz D Ghanchi; Dinesh M Parmar; Suresh D Mistry
Journal:  Ann Thorac Med       Date:  2011-10       Impact factor: 2.219

5.  Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice.

Authors:  F W Riemslagh; E C van der Toorn; R F M Verhagen; A Maas; L W J Bosman; R K Hukema; R Willemsen
Journal:  Dis Model Mech       Date:  2021-01-11       Impact factor: 5.758
  5 in total

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