Literature DB >> 6745298

Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels.

P De Nayer, P Malvaux, C Beckers.   

Abstract

Free-T4 levels were determined in familial dysalbuminemic hyperthyroxinemia (FDH) subjects. In agreement with their euthyroid status free-T4 levels were within the normal range when tested by equilibrium dialysis and by the FT4 Immophase method (Corning Medical). However, when using the recently introduced "analog" methods, either Amerlex FT4 or Becton-Dickinson FT4, Free-T4 values were markedly higher than the control values. This discrepancy is probably due to artifactual binding of the labeled analog to the fraction of albumin exhibiting an excessive affinity for T4.

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Year:  1984        PMID： 6745298     DOI： 10.1007/BF00803252

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  12 in total

1.  BINDING OF THYROXINE BY SERUM PROTEINS EVALUATED BY EQUILIBRUM DIALYSIS AND ELECTROPHORETIC TECHNIQUES. ALTERATIONS IN NONTHYROIDAL ILLNESS.

Authors:  J H OPPENHEIMER; R SQUEF; M I SURKS; H HAUER
Journal:  J Clin Invest       Date:  1963-11       Impact factor: 14.808

2.  Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin.

Authors:  J R Stockigt; D J Topliss; J W Barlow; E L White; D M Hurley; P Taft
Journal:  J Clin Endocrinol Metab       Date:  1981-08       Impact factor: 5.958

3.  Effect of anti-thyroxin autoantibodies on radioimmunoassay of free thyroxin in serum.

Authors:  J Konishi; Y Iida; T Kousaka; K Ikekubo; T Nakagawa; K Torizuka
Journal:  Clin Chem       Date:  1982-06       Impact factor: 8.327

4.  Hyperthyroxinemia associated with high thyroxine binding to albumin in euthyroid subjects.

Authors:  P De Nayer; P Malvaux
Journal:  J Endocrinol Invest       Date:  1982 Nov-Dec       Impact factor: 4.256

5.  Limitations of a new free thyroxine assay (Amerlex free T4).

Authors:  J R Stockigt; M de Garis; J Csicsmann; J W Barlow; E L White; D M Hurley
Journal:  Clin Endocrinol (Oxf)       Date:  1981-09       Impact factor: 3.478

6.  Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis.

Authors:  M Ruiz; R Rajatanavin; R A Young; C Taylor; R Brown; L E Braverman; S H Ingbar
Journal:  N Engl J Med       Date:  1982-03-18       Impact factor: 91.245

7.  "Unbound analog" radioimmunoassays for free thyroxin measure the albumin-bound hormone fraction.

Authors:  J R Stockigt; V Stevens; E L White; J W Barlow
Journal:  Clin Chem       Date:  1983-07       Impact factor: 8.327

8.  Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.

Authors:  G Hennemann; R Docter; E P Krenning; G Bos; M Otten; T J Visser
Journal:  Lancet       Date:  1979-03-24       Impact factor: 79.321

9.  Familial hyperthyroxinemia due to abnormal thyroid hormone binding.

Authors:  J D Silverberg; B N Premachandra
Journal:  Ann Intern Med       Date:  1982-02       Impact factor: 25.391

10.  Effect of albumin concentration on the assay of serum free thyroxin by equilibrium radioimmunoassay with labeled thyroxin analog (Amerlex Free T4).

Authors:  N Amino; K Nishi; K Nakatani; H Mizuta; K Ichihara; O Tanizawa; K Miyai
Journal:  Clin Chem       Date:  1983-02       Impact factor: 8.327
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  1 in total

Review 1.  Familial dysalbuminaemic hyperthyroxinaemia: a review.

Authors:  I W Jensen; J Faber
Journal:  J R Soc Med       Date:  1988-01       Impact factor: 18.000
  1 in total

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