Literature DB >> 6744674

The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen.

B Henderson, N A Staines, I Burrai, J H Cox.   

Abstract

The influence of cyclosporine (CsA) on the induction and pathogenesis of type II collagen-induced arthritis has been investigated in inbred and outbred Wistar rats. The proportion of animals developing disease and the severity of disease they developed were both diminished by treatment with CsA. These effects were accompanied by a marked suppression of the antibody response to both the immunizing collagen and also to rat type II collagen. CsA treatment also resulted in a decreased accumulation of lymphocytes in arthritic joints. The results indicate that the anti-arthritic and immunosuppressive effects of CsA probably result from a modification of both systemic antibody-mediated and local cell-mediated immunity.

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Year:  1984        PMID： 6744674      PMCID： PMC1536083     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  15 in total

1.  Passive transfer by cells of type II collagen-induced arthritis in rats.

Authors:  D E Trentham; R A Dynesius; J R David
Journal:  J Clin Invest       Date:  1978-08       Impact factor: 14.808

2.  Effect of psychological stress on the induction of arthritis in rats.

Authors:  M P Rogers; D E Trentham; W J McCune; B I Ginsberg; H G Rennke; P Reich; J R David
Journal:  Arthritis Rheum       Date:  1980-12

3.  Native type II collagen-induced arthritis in the rat. II. Relationship between the humoral immune response to native type II collagen and arthritis.

Authors:  R B Clague; K Morgan; M J Shaw; P J Holt
Journal:  J Rheumatol       Date:  1980 Nov-Dec       Impact factor: 4.666

4.  Autoimmunity to collagen in adjuvant arthritis of rats.

Authors:  D E Trentham; W J McCune; P Susman; J R David
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

5.  Collagen-induced arthritis in the rat: modification of immune and arthritic responses by free collagen and immune anti-collagen antiserum.

Authors:  N A Staines; T Hardingham; M Smith; B Henderson
Journal:  Immunology       Date:  1981-12       Impact factor: 7.397

6.  Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats.

Authors:  D E Trentham; A S Townes; A H Kang; J R David
Journal:  J Clin Invest       Date:  1978-01       Impact factor: 14.808

7.  Collagen-induced arthritis in rats. Evaluation of early immunologic events.

Authors:  J M Stuart; M A Cremer; A H Kang; A S Townes
Journal:  Arthritis Rheum       Date:  1979-12

8.  Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis.

Authors:  J M Stuart; M A Cremer; A S Townes; A H Kang
Journal:  J Exp Med       Date:  1982-01-01       Impact factor: 14.307

9.  Thymus independence of a collagen-like synthetic polypeptide and of collagen, and the need for thymus and bone marrow-cell cooperation in the immune response to gelatin.

Authors:  S Fuchs; E Mozes; A Maoz; M Sela
Journal:  J Exp Med       Date:  1974-01-01       Impact factor: 14.307

10.  Serum transfer of collagen-induced arthritis in mice.

Authors:  J M Stuart; F J Dixon
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307
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  10 in total

1.  Low-affinity antibodies against collagen type II produced by lymph node cells are associated with pathology in collagen-induced arthritis in rats.

Authors:  J Rahman; J Loh; N A Staines
Journal:  Clin Exp Immunol       Date:  1992-06       Impact factor: 4.330

2.  Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats.

Authors:  H S Thompson; N A Staines
Journal:  Clin Exp Immunol       Date:  1986-06       Impact factor: 4.330

3.  Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.

Authors:  A W van Rijthoven; B A Dijkmans; H S Goei The; J Hermans; Z L Montnor-Beckers; P C Jacobs; A Cats
Journal:  Ann Rheum Dis       Date:  1986-09       Impact factor: 19.103

4.  Regulation of resistance against adjuvant arthritis in the Fisher rat.

Authors:  A G van de Langerijt; P L van Lent; A R Hermus; L B van de Putte; W B van den Berg
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

Review 5.  Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.

Authors:  Diana Faulds; Karen L Goa; Paul Benfield
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546

6.  Interleukin 1 mediated acceleration of type II collagen-induced arthritis: effects of anti-inflammatory or anti-arthritic drugs.

Authors:  J T Hom; V L Gliszczynski; H W Cole; A M Bendele
Journal:  Agents Actions       Date:  1991-07

7.  Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients.

Authors:  M Dougados; H Awada; B Amor
Journal:  Ann Rheum Dis       Date:  1988-02       Impact factor: 19.103

8.  The anti-arthritic and immunosuppressive effects of cyclosporin A on collagen-induced arthritis in the rhesus monkey.

Authors:  N P Bakker; N Van Besouw; R Groenestein; M Jonker; L A Hart
Journal:  Clin Exp Immunol       Date:  1993-09       Impact factor: 4.330

9.  Tolerogenic activity of polymerized type II collagen in preventing collagen-induced arthritis in rats.

Authors:  H S Thompson; B Henderson; J M Spencer; S M Hobbs; J V Peppard; N A Staines
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

10.  Effects of cyclosporin on collagen induced arthritis in mice.

Authors:  K Takagishi; N Kaibara; T Hotokebuchi; C Arita; M Morinaga; K Arai
Journal:  Ann Rheum Dis       Date:  1986-04       Impact factor: 19.103
  10 in total

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