Anti-neoplastic activity of C205: a new topical anti-cancer formulation.

C205, a topical ointment currently in clinical trial, was tested by a method developed to evaluate the topical activity of new drugs. Subcutaneous B-16 melanoma was used as the primary tumor model. Tumor size of treated animals as percentage of tumor size of control animals (T/C ratio) was found to be 14, with 50% of the animals tested free of viable and palpable tumor at 60 days post treatment. The anti-neoplastic activity of C205 was superior to 5-fluorouracil using the same method of evaluation. Only minimal loss of animal body weight occurred after C205. C205 also showed anti-tumor activity against subcutaneously implanted Lewis lung carcinoma.