| Literature DB >> 6743784 |
R R Berardi, I A Cohen, M L Hyneck, G F Lockwood, U A Shukla, E Sakmar, J J Wells, J G Wagner.
Abstract
A two-way crossover bioavailability study of two commercial cimetidine formulations was performed on 24 healthy male volunteers. Drug was administered after an overnight fast and plasma samples were withdrawn periodically for 12 h. Urine was collected throughout the study period. Results indicated that the two formulations were bioequivalent since no statistically significant difference in means was detected for any of the parameters studied. Extensive interpatient variation in cimetidine blood concentration was observed during both treatments.Entities:
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Year: 1984 PMID： 6743784 DOI： 10.1002/bdd.2510050210
Source DB: PubMed Journal: Biopharm Drug Dispos ISSN： 0142-2782 Impact factor: 1.627