Literature DB >> 6743231

Species differences in the occurrence of copper-metallothionein in the particulate fractions of the liver of copper-loaded animals.

R K Mehra, I Bremner.   

Abstract

Large amounts of Cu-metallothionein were obtained by 2-mercaptoethanol and sodium dodecyl sulphate extractions of the particulate fractions of the liver of pigs given high-Cu2+ diets or rats injected with Cu2+. Three isoproteins were purified from pig liver and characterized on the basis of their physicochemical properties, metal content and amino acid composition. No such pool of Cu-metallothionein was present in the liver of Cu2+-loaded sheep or of rats given Cu2+-supplemented diets.

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Year:  1984        PMID: 6743231      PMCID: PMC1153511          DOI: 10.1042/bj2190539

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  22 in total

1.  Isolation of (copper, zinc-) thioneins from pig liver.

Authors:  I Bremner; B W Young
Journal:  Biochem J       Date:  1976-06-01       Impact factor: 3.857

2.  The particulate half-cystine-rich copper protein of newborn liver. Relationship to metallothionein and subcellular localization in non-mitochondrial particles possibly representing heavy lysosomes.

Authors:  H Porter
Journal:  Biochem Biophys Res Commun       Date:  1974-02-04       Impact factor: 3.575

3.  Copper in hepatocyte lysosomes of the toad, Bufo marinus L.

Authors:  S Goldfischer; B Schiller; I Sternlieb
Journal:  Nature       Date:  1970-10-10       Impact factor: 49.962

4.  The experimental production of zinc deficiency in the rat.

Authors:  R B Williams; C F Mills
Journal:  Br J Nutr       Date:  1970-12       Impact factor: 3.718

5.  Intracellular distribution of copper in the liver during chronic administration of copper sulfate to the rat.

Authors:  S Lal; T L Sourkes
Journal:  Toxicol Appl Pharmacol       Date:  1971-03       Impact factor: 4.219

6.  The relationship between the zinc status of pigs and the occurrence of copper- and Zn-binding proteins in liver.

Authors:  I Bremner
Journal:  Br J Nutr       Date:  1976-03       Impact factor: 3.718

7.  Protective effect of zinc supplementation against copper toxicosis in sheep.

Authors:  I Bremner; B W Young; C F Mills
Journal:  Br J Nutr       Date:  1976-11       Impact factor: 3.718

8.  Effects of dietary molybdenum and sulphur on the distribution of copper in plasma and kidneys of sheep.

Authors:  I Bremner; B W Young
Journal:  Br J Nutr       Date:  1978-03       Impact factor: 3.718

9.  Changes in the distribution of hepatic copper in relation to the progression of Wilson's disease (hepatolenticular degeneration).

Authors:  S Goldfischer; I Sternlieb
Journal:  Am J Pathol       Date:  1968-12       Impact factor: 4.307

10.  Hepatic copper- and zinc-binding proteins in ruminants. 2. Relationship between Cu and Zn concentrations and the occurrence of a metallothionein-like fraction.

Authors:  I Bremner; R B Marshall
Journal:  Br J Nutr       Date:  1974-09       Impact factor: 3.718

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  8 in total

1.  Influence of zinc on copper binding in tissue proteins of steers.

Authors:  P D Whanger; J T Deagen
Journal:  Biol Trace Elem Res       Date:  1991-02       Impact factor: 3.738

2.  Broiler responses to copper levels and sources: growth, tissue mineral content, antioxidant status and mRNA expression of genes involved in lipid and protein metabolism.

Authors:  Helvio da Cruz Ferreira Júnior; Diego Ladeira da Silva; Bruno Reis de Carvalho; Haniel Cedraz de Oliveira; Jorge Cunha Lima Muniz; Warley Junior Alves; James Eugene Pettigrew; Simone Eliza Facione Guimarães; Gabriel da Silva Viana; Melissa Izabel Hannas
Journal:  BMC Vet Res       Date:  2022-06-13       Impact factor: 2.792

3.  Induction of metallothionein mRNA in rat liver and kidney after copper chloride injection.

Authors:  S A Wake; J F Mercer
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

4.  Studies on the metabolism of rat liver copper-metallothionein.

Authors:  R K Mehra; I Bremner
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

5.  Effect of dietary fish on the lipid profile of cholesterolstressed rats during copper overload.

Authors:  M Nandini; M A Rahiman; S N Rao
Journal:  Indian J Clin Biochem       Date:  2000-07

6.  Isolation, characterization, and determination of human liver (copper/zinc) metallothionein.

Authors:  T P Mulder; A R Janssens; H W Verspaget; C B Lamers
Journal:  Experientia       Date:  1990-07-15

7.  Effects of dietary copper supplementation of rats on the occurrence of metallothionein-I in liver and its secretion into blood, bile and urine.

Authors:  I Bremner; R K Mehra; J N Morrison; A M Wood
Journal:  Biochem J       Date:  1986-05-01       Impact factor: 3.857

8.  Biliary excretion of metallothionein and a possible degradation product in rats injected with copper and zinc.

Authors:  M Sato; I Bremner
Journal:  Biochem J       Date:  1984-10-15       Impact factor: 3.857

  8 in total

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