Literature DB >> 6737997

The determination of 4,4'-methylenebis (2-chloroaniline) in urine by electron capture gas chromatography.

W Gristwood, S M Robertson, H K Wilson.   

Abstract

The development and use of a gas chromatographic method for monitoring workers who are occupationally exposed to 4,4'-methylenebis(2-chloroaniline) (MBOCA) is reported. The increase in ether-extractable MBOCA on mild hydrolysis is determined. The analytical conditions for a specific and sensitive electron capture gas chromatographic method that will measure both "free" MBOCA and "total" MBOCA are established. It is suggested that workers should be monitored by the measurement of "total" urinary MBOCA.

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Year:  1984        PMID: 6737997     DOI: 10.1093/jat/8.3.101

Source DB:  PubMed          Journal:  J Anal Toxicol        ISSN: 0146-4760            Impact factor:   3.367


  3 in total

1.  Unlabeled hemoglobin adducts of 4,4'-methylenebis (2-chloroaniline) in rats and guinea pigs.

Authors:  T H Chen; B I Kuslikis; W E Braselton
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

2.  Evidence that a beta-N-glucuronide of 4,4'-methylenebis (2-chloroaniline) (MbOCA) is a major urinary metabolite in man: implications for biological monitoring.

Authors:  J Cocker; A R Boobis; H K Wilson; D Gompertz
Journal:  Br J Ind Med       Date:  1990-03

3.  Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.

Authors:  J Cocker; W Gristwood; H K Wilson
Journal:  Br J Ind Med       Date:  1986-09
  3 in total

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